DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	560	Identity:	166/560 - (29%)
Similarity:	270/560 - (48%)	Gaps:	55/560 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIIC-SVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQ 64
            |.|:::|.|:..||.:||:::| :.|...:|.|  |.....||||.|.|.|.:..|     |...
Zfish     1 MRFEDLLSELNGFGRFQKMVLCINFLGRFSLGC--HFLLGNFIAAIPSHHCNISSL-----DVDG 58

  Fly    65 LVKNLS--------IPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLL--RQQAEDLLKLQPDT 119
            :.:|||        :|...:|..|.|.|:|            .|...||  ...:.||
Zfish    59 VFENLSQEERLTVGVPAQEDGTPASCHMFS------------HPQFQLLINSSSSSDL------- 104

  Fly   120 TQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPS 184
             .||.||:|||:|.|.:.||:..:|:||||:..|..|...:|.:|.:.|...||.|..::||:|.
Zfish   105 -PVVECQNGWHFDNSTFISTLATQWDLVCDKRALGKLTTTIFFLGVMFGAAAFGSLSAMFGRKPM 168

  Fly   185 FYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIA 249
            .....:|.:.....|..:.:...:..|||..|.|:...:....||.:|.|..|.|....::.::|
Zfish   169 LLVSYILGMGFGLCSVLSSSLVMFAVLRFFSGFTITGSVIISTVLNVEWVSIEHRKLVGVIDSLA 233

  Fly   250 YSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARV 314
            ::.|.:....:.|.:||||.|::|:|:|.::....::.:|||.|||:..||..:|...||..|.:
Zfish   234 WTFGFMGFPVIAYFIRDWRWLTVAISLPNVISIITWWWVPESARWLIVNGKADKAHYYLKKCAAM 298

  Fly   315 NGVRVNRDFVERLQ----RKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSV 375
            |.   .::...|::    .|:::|.....|      |..|||.|.|.|||.:|:..:.||:..:|
Zfish   299 NH---KKEVTARIKPEDLSKIIVTDRGSRK------YSYLDLVRTPKMRRLSLLTGITWFSVATV 354

  Fly   376 YVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD 440
            ..|:|:.....|.:.....|:.||:|:|....::..|..|||......|:|..|::.:.....|.
Zfish   355 AYGISFNITGFGLNMYLTQFVYGAIEIPAKFCIYYLLDKFGRHVTQAGSLLFVGISFIINIFIPK 419

  Fly   441 ----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQM 501
                |..::..:||...::||..:.|..|||||||||..||.::|.|:..|..|.|:|.......
Zfish   420 EKTVIRTVIAVLGKGCSATSFGTVILYTSELYPTVVRQNGMGYTSFIARFGVSVAPLILLSNDVW 484

  Fly   502 LVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAV 541
            .....:::..|.:...|.:..||||..:.||:|:::.|.:
Zfish   485 SYFSQVILCFLALSAAFVAYQLPETSGKCLPETIDDIEGI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	118/403 (29%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	160/540 (30%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	105/372 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840