DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17575 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_001188917.1	Gene:	CG17575 / 36414	FlyBaseID:	FBgn0250842	Length:	298	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	306	Identity:	68/306 - (22%)
Similarity:	102/306 - (33%)	Gaps:	99/306 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PLLLLLMLLGQQLQAFDYCDPTLCPGPERHIACNNFGALADICSPDAHIVRITTARRT------- 65
            ||.||.::.|.|    .|..|             |...|.::.|...|....:..||.
Human    10 PLGLLFLVCGSQ----GYLLP-------------NVTLLEELLSKYQHNESHSRVRRAIPREDKE 57

  Fly    66 ---MILNELNEYRDRIARGDLMGFSPATRMATLQWDQELASFAELNVKRCALVNDHCRNSEQFRN 127
               |:.|:|        ||.:.  ..|:.|..:.||.||...|.....:|  :.:|...|.....
Human    58 EILMLHNKL--------RGQVQ--PQASNMEYMTWDDELEKSAAAWASQC--IWEHGPTSLLVSI 110

  Fly   128 VAQVVAEGGWQGDPLPPSSPSDPPNPEAPIPVEYHTE---DEVIKATLEQMFAEYKECSMRDIIA 189
            ...:.|..|....|                  .:|.:   |||...|    :....||:     .
Human   111 GQNLGAHWGRYRSP------------------GFHVQSWYDEVKDYT----YPYPSECN-----P 148

  Fly   190 FSPPNNRILRLRVSKC----IAYFTQLVRDSTTHVGCGILRQTKNTT-NEAGQSLSSVHQYMTCN 249
            :.|          .:|    ..::||:|..:|..:||.:....|.|. .|..::.    .|..||
Human   149 WCP----------ERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENA----VYFVCN 199

  Fly   250 F-VRTNDVNAPVYQSGDRPATEC-----RSGRNPVFINLCSVNEIY 289
            : .:.|.:....|::| ||.:||     .|.||    |||...|.|
Human   200 YSPKGNWIGEAPYKNG-RPCSECPPSYGGSCRN----NLCYREETY 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17575	NP_001188917.1	SCP_euk	64..250	CDD:240180	39/203 (19%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	39/197 (20%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10334
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850