Protein Alignment Cyp9h1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 159/597 - (26%)
• Similarity: 277/597 - (46%)
• Gaps: 116/597 - (19%)

  Fly     5 MIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPL--KAMIGGMPVLKKMIELHTK 67
            |:.:||.:.||.||..:|.:.:....:.|:.|.||.|.|||:..  :........|:|:.
Human    15 MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY----- 74

  Fly    68 HTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRWKE 132
               .|:.|.|..|.....:.:|::||.:.::.|.:|.|.  |.:.::...::.|::.|||.||:|
Human    75 ---GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR--MASGLEFKSVADSVLFLRDKRWEE 134

  Fly   133 MRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLE---------------------------- 169
            :|..|..||:..|:          :|.|::.:||:::
Human   135 VRGALMSAFSPEKL----------NELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLH 189

  Fly   170 -----------LSQDASIEL-EMKDY------------FTRFANDVIATVAFGISINSFRRKDNE 210
                       :||...:.| .:|.|            :..:..||:|:||||..::|::..::.
Human   190 YATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 254

  Fly   211 FFRIGQAMSRISAWSVVKAMLYAL--FPRLMKVLRIQVLDTKNID----YFSSLV--TAAMRYRQ 267
            |.:   ...|...:.:.:.:|..|  ||.:|..| .::|..||.|    :|:.|:  ..|:|.:|
Human   255 FVK---HCKRFFEFCIPRPILVLLLSFPSIMVPL-ARILPNKNRDELNGFFNKLIRNVIALRDQQ 315

  Fly   268 EHKVVRPDMIHLLMEAKQQR----------LADL----------SDKSKDELYYSEFTADDLLAQ 312
            ..:..|.|.:.::::|:...          :.|:          |.:.:........|.|:::.|
Human   316 AAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQ 380

  Fly   313 CLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVL 377
            ..:|..||:|||:::|.|.|:.|..||..|::|..| :.|.:|....|........:.|||||:.
Human   381 AFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE-VDVFKEKHMAPEFCSLEEGLPYLDMVIA 444

  Fly   378 EALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFA 442
            |.||.:||:....||..||.::.   ||::   ..|.||::.:.:||||||::..||.||||||.
Human   445 ETLRMYPPAFRFTREAAQDCEVL---GQRI---PAGAVLEMAVGALHHDPEHWPSPETFNPERFT 503

  Fly   443 DGHALESR--VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLK 505
            .....:.|  .|:|||.|||:|:|.|:.|:|:|..:..:|..|:......|...|..:.:. .|.
Human   504 AEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALG 567

  Fly   506 PKNGFWLKFEAR 517
            ||||.::|..:|
Human   568 PKNGVYIKIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	CYP6-like	69..511	CDD:410679	139/523 (27%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	139/531 (26%)