Protein Alignment Cyp9h1 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 159/523 - (30%)
• Similarity: 262/523 - (50%)
• Gaps: 64/523 - (12%)

  Fly    15 LVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKHTGSPVYGIYAL 79
            |||||.:....:.:|.:.|:....|.|.:|.|..  .:.|:....:  |.:.|:  ..::|:|..
Human    19 LVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILF--YLRGLWNFDR--ECNEKY--GEMWGLYEG 77

  Fly    80 RDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMRNILTPAFTG 143
            :..:..:.||::||.:.:|| :..|.|...:.   ....|..:|....|..||.:|.:|:||||.
Human    78 QQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG---PMGFLKSALSFAEDEEWKRIRTLLSPAFTS 139

  Fly   144 SKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGISINSFRRKD 208
            .|.:.|..:|..|.:..|..::::.|.|:    .:.:||:|..:..|||....||::::|.....
Human   140 VKFKEMVPIISQCGDMLVRSLRQEAENSK----SINLKDFFGAYTMDVITGTLFGVNLDSLNNPQ 200

  Fly   209 NEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLVT------------A 261
            :.|.:..:.:.::...... .:|.:|||.|     ..|.:..||..|...||            :
Human   201 DPFLKNMKKLLKLDFLDPF-LLLISLFPFL-----TPVFEALNIGLFPKDVTHFLKNSIERMKES 259

  Fly   262 AMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISS 326
            .::.:|:|:|   |..        |::.| |..||:...:...:..:|:||.::..||.::..|:
Human   260 RLKDKQKHRV---DFF--------QQMID-SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTST 312

  Fly   327 SLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPPSISTD 390
            :|.|:.:||..:|.||.:|.|||.:|   |..: |:|||.|.:|:||||||.|.||.:|......
Human   313 TLPFIMYELATHPDVQQKLQEEIDAV---LPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

  Fly   391 RECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPE-RFA--DGHALESRVY 452
            |.|::||::   ||..:   .||..:.:||::|||||:.:.:||.|.|| ||:  :..:::...|
Human   375 RVCKKDIEI---NGVFI---PKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRY 433

  Fly   453 MPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLND---IRGHGLKPKNGFWLKF 514
            :|||.|||||||.|.||..:|..|.:.|.||...|.|.|...|..|   |    |:|:....||.
Human   434 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI----LQPEKPIVLKV 494

  Fly   515 EAR 517
            ..|
Human   495 HLR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	149/493 (30%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	150/498 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770