DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	561	Identity:	149/561 - (26%)
Similarity:	244/561 - (43%)	Gaps:	124/561 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLVLLYKWSVAK-----YDVFSERGVSHEKPWP-----LIGNIPLKAMIGGM--PVLKKMIELHT 66
            ||:|...|.:|:     |..:......|..|.|     |:|::       ||  |..:.:.|| |
Mouse    22 LLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHV-------GMVTPTEQGLKEL-T 78

  Fly    67 KHTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKS-LISLRD--- 127
            :..|:...|        |.:....::.:|.:           .|::|..|||:.| .::|:|
Mouse    79 RLVGTYPQG--------FLMWIGPMVPVITL-----------CHSDIVRSILNASAAVALKDVIF 124

  Fly   128 -----------------GRWKEMRNILTPAFTGSKMRIMYDLIQSCSEE-GVIHIQEQLELSQDA 174
                             .:|...|.:|||||   ...|:...::..::. .::|.:.| .|..|.
Mouse   125 YSILKPWLGDGLLVSAGDKWSRHRRMLTPAF---HFNILKPYVKIFNDSTNIMHAKWQ-RLISDG 185

  Fly   175 SIELEMKDYFTRFANDVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKA---------M 230
            |..|:|.::.:....|.:....|....|. :.|.:|:.   .|:..:|| .|.|.         :
Mouse   186 SARLDMFEHVSLMTLDSLQKCVFSFDSNC-QEKSSEYI---AAILELSA-LVAKRHQQPLMFMDL 245

  Fly   231 LYALFP---RLMKVLRIQVLDTKNIDYFSSLVTAAMRYRQEHKVVRPDM---IHLLMEAKQQRL- 288
            ||.|.|   |..|...:       :..|:..|     .|:.|:.: ||.   ..|..:||.:.|
Mouse   246 LYNLTPDGMRFRKACNV-------VHEFTDAV-----IRERHRTL-PDQGLDDFLKSKAKSKTLD 297

  Fly   289 -ADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISV 352
             .|:...|||| ...|.:.:|:.|:...|.|.|.:..:|.|.::.:.|..:|..|:|..:|   |
Mouse   298 FIDVLLLSKDE-DGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQE---V 358

  Fly   353 HEELKG---QPLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGD 414
            .|.|:|   :.:.:|.|.::.:|.|.:.|:||..||.....|.|.|||.|.|  |:.:   .||.
Mouse   359 QELLRGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPD--GRTI---PKGI 418

  Fly   415 VLQIPIFSLHHDPENFEDPEFFNPERFADGHALESR--VYMPFGVGPRNCIGNRMALMELKSIVY 477
            :..|.||.:||:|..:.|||.::|.||...:..:|.  .::||..|||||||...|:.|:|..:.
Mouse   419 ICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALA 483

  Fly   478 QLLLNFKLLPAKRTSR---DLLNDIRGHGLKPKNGFWLKFE 515
            ..||.|:|||..:..|   :|:       |:.:.|.||:.|
Mouse   484 LTLLRFRLLPDDKEPRRQPELI-------LRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	139/527 (26%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	138/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900