DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	543	Identity:	152/543 - (27%)
Similarity:	267/543 - (49%)	Gaps:	69/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQSMIALA--LFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIG----GMPVLK 59
            :|.|.:::.  |.:::|.|||.:.|..:..|.:.|:...:|||..|.. |....|    .|...|
Zfish     2 IDLSSLSVTWILVVLVLTLLYMYGVWPHGFFKKLGIPGPRPWPFFGTF-LSYTKGFFNFDMECAK 65

  Fly    60 KMIELHTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLI 123
            |.         ..|:|||..|..:..|.|.|:||.|.:|| :..|.|...::.:: ...|:..:.
Zfish    66 KY---------GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDL-AGPLADGIT 120

  Fly   124 SLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFA 188
            :::|.|||.:|..|:|.||..:::.::.:..:.::..:.::|:     .|....:::|:....::
Zfish   121 AVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQK-----GDHEQPVKIKEVMASYS 180

  Fly   189 NDVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKV----------LR 243
            .||:.:.||.:.|:|....|:.|      ::.|.  :.:|..|:.||..|:.|          :.
Zfish   181 LDVVTSSAFSVDIDSINNPDDPF------VTNIK--NFLKFNLFGLFVLLLTVFPSIANLLGKMG 237

  Fly   244 IQVLDTKNIDYFSSLVTAAMRYRQEHKVV--RPDMIHLLMEAKQQRLADLSDKSKD---ELYYSE 303
            :.:.....:|:|   ..|..:.::|||..  |.|...|::   |..:.|  |:.||   |.....
Zfish   238 LSMFSKPTVDFF---YKALRKIKEEHKDSNGRVDFFRLMI---QNEIPD--DQVKDTTSEQPEKG 294

  Fly   304 FTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTK 368
            .|..::|:|..:|...|:|..|::|.||.:.|.:||...::|.|:|.....  ...|::||.|.|
Zfish   295 LTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFP--LDTPISYDALMK 357

  Fly   369 MKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDP 433
            :.||:|.:.|::|..|.:...:|.|::.:::   ||   .:..|..::.||.:.|:.||:.::.|
Zfish   358 IDYLEMSINESMRLLPTAPRLERVCKKTVEM---NG---ITIPKDTMITIPTYVLNQDPQLWDSP 416

  Fly   434 EFFNPERFADGHALE--SRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDL- 495
            ..|.||||:..:..|  ...:||||:|||||||.|.|||.:|.:|.:||.||.:...|.|...|
Zfish   417 HEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLE 481

  Fly   496 LNDIRGHGLKPKNGFWLKFEARQ 518
            ||.:    .:||....||...|:
Zfish   482 LNPV----FQPKVPITLKLTPRK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	139/496 (28%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	140/501 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910