DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp3a41a

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_059092.2	Gene:	Cyp3a41a / 53973	MGIID:	1858451	Length:	504	Species:	Mus musculus

Alignment Length:	524	Identity:	158/524 - (30%)
Similarity:	279/524 - (53%)	Gaps:	44/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKH 68
            |:....|..|:|||||::....:.:|.::|:...||.|.:|.: |....|   :.|..:|.:.|:
Mouse     8 SLDTWVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTV-LNYYKG---LWKFDMECYEKY 68

  Fly    69 TGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKE 132
              ...:|::..:..:|.:.|||:||.:.:|| |..|.|.....   ...|:||::...:|..||.
Mouse    69 --GKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFG---PVGIMSKAISISKDEEWKR 128

  Fly   133 MRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAF 197
            .|.:|:|.||..|::.|:.:|:...:..|.::.::.|..:..:    |||....::.|||.:.:|
Mouse   129 YRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVT----MKDVLGAYSIDVITSTSF 189

  Fly   198 GISINSFRRKDNEFFRIGQAMSRISAWS--VVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLVT 260
            |::::|....::.|....:.:.|:..:.  |...:|:.....:.::|.|.:....:|::|...|.
Mouse   190 GVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVN 254

  Fly   261 ----AAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGF 321
                :.:..:|:|:|   |.:.|:|.|        .:.|||:..:...:..::.||.::|.|||:
Mouse   255 RMKESRLDSKQKHRV---DFLQLMMNA--------HNNSKDKDSHKALSDMEITAQSIVFIFAGY 308

  Fly   322 EIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPP 385
            |..||:|.|..:.|..:|.:|.:|.|||   .|.|..: |.|||.:.:|:|||||:.|.||.:|.
Mouse   309 ETTSSTLSFTLYCLATHPDIQKKLQEEI---DETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPI 370

  Fly   386 SISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGH--ALE 448
            ....:|.|::|::|   ||..:   .||..:.||.::|||||:::.:||.|.||||:..:  :::
Mouse   371 GNRLERFCKKDVEL---NGVYI---PKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSID 429

  Fly   449 SRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFWLK 513
            ..:|||||:|||||||.|.|.|.:|..:.:::.||...|.:.|...|....:|. |:|:....||
Mouse   430 PYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGL-LQPEKPIVLK 493

  Fly   514 FEAR 517
            ...|
Mouse   494 VVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	145/483 (30%)
Cyp3a41a	NP_059092.2	p450	39..494	CDD:278495	146/488 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.770