DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	227/525 - (43%)
Similarity:	333/525 - (63%)	Gaps:	32/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKK-----MIELHTKH 68
            |||.|...|.|:|:.|..|.|.:||:::|||....||      :.||.:.|:     :.:|:||.
  Fly     7 ALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGN------MAGMFLRKRAMFDIVCDLYTKG 65

  Fly    69 TGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSM---------HNNIQESILSKSLIS 124
            .....:||:..|..:..||||:|||.|.||:||||:||.::         |:  ..::...||.|
  Fly    66 GSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHD--MSNLFGSSLFS 128

  Fly   125 LRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFAN 189
            :||.|||:||:.|:|||||||||.|:.|:...::|.|..:::.....|:.  ||:||||.|||.|
  Fly   129 MRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQEN--ELDMKDYCTRFTN 191

  Fly   190 DVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDY 254
            ||||:.|||:.:|||:.::|.|:::|:.::..:....:|.||:.....|.|:|::::.|.|:..|
  Fly   192 DVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKGLNKILKVELFDRKSTQY 256

  Fly   255 FSSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFA 319
            |..||..||:|||||.:||||||::||||   |....::|:|... ..|::..|::|||.:||||
  Fly   257 FVRLVLDAMKYRQEHNIVRPDMINMLMEA---RGIIQTEKTKASA-VREWSDRDIVAQCFVFFFA 317

  Fly   320 GFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWP 384
            |||..:..:||..|||..|..||.|||||:..|.::|:|:.|||:.:..|||||.||.|.|||||
  Fly   318 GFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWP 382

  Fly   385 PSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGH--AL 447
            .:|:.||||.:|| .||.:|||: ..:||||:.:|....|.||:.||:|..|:||||:|.:  ::
  Fly   383 AAIAVDRECNKDI-TFDVDGQKV-EVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESI 445

  Fly   448 ESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFWL 512
            :...|.|||:|.|||||:|.||:|.|:::|.||.:::..|||::...|.....|..|.||.|||:
  Fly   446 QPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWI 510

  Fly   513 KFEAR 517
            |...|
  Fly   511 KLVQR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	211/489 (43%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	211/489 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469070
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D21895at7147
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800