DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	542	Identity:	120/542 - (22%)
Similarity:	210/542 - (38%)	Gaps:	103/542 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IILLVLLYKWSVAKYDVFSERGVSHEKPWP------LIGNIPLKAMIG-GMPVLKKMIELHTKHT 69
            |.|..||   :|.|..:...:||...:.:|      |.|::......| .:..:.|.:||:  ..
Zfish    20 IFLACLL---TVVKLLIVRRKGVKTMERFPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELY--QF 79

  Fly    70 GSPVYGIYALRDAVFFVRDPELIKLI----------GIKEFDHFVNHNSMHNNIQESILSKSLIS 124
            ..|::  :....||..:..|..:|.|          ..|.|..:              |...|:.
Zfish    80 AFPLW--FGPSLAVLNIHHPSYVKTILTTTEPKDDYAYKFFIPW--------------LGDGLLV 128

  Fly   125 LRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFAN 189
            ....:|...|.:|||.|....::....||...::.    :.::.|:...:....|:..:.:....
Zfish   129 STGQKWFRHRRLLTPGFHYDVLKPYVKLISDSTKV----MLDKWEVHSRSEESFELFKHVSLMTL 189

  Fly   190 DVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKV-LRIQVLDTKNID 253
            |.|...||  |.||..:.|                |.....:.|:|.....| ||.:|     ..
Zfish   190 DSIMKCAF--SCNSNCQTD----------------SGTNPYIQAVFDLCHLVNLRFRV-----FP 231

  Fly   254 YFSSLV------------TAAMRYRQEHKVVRPDMIHLLME-----AKQQRLADLSD---KSKDE 298
            |.|..:            .|::.:....:|:|.....|.||     .|.:|..|..|   .::||
Zfish   232 YHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQGIVKNRRYLDFLDILLSARDE 296

  Fly   299 LYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLT 362
             :....:.:|:.|:...|.|.|.:..:|.:.::.:.|..||..|::..:||   .:.|.|: .|.
Zfish   297 -HQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEI---QQALDGKATLE 357

  Fly   363 YDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDP 427
            ::.|.|:.|..|.:.|:||..||.....|:..:.:..||..     :..:|..:.:.|:.:|.:.
Zfish   358 WEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPLTFFDGR-----TVPEGCTIGVSIYGIHMNS 417

  Fly   428 ENFEDPEFFNPERFADGHAL--ESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLL---- 486
            ..:|:|..|:|.||...:..  ....::||..|||||||...|:.|:|..|...|..:.|:
Zfish   418 TVWENPYKFDPLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRYYLIKDPD 482

  Fly   487 -PAKRTSRDLLNDIRGHGLKPK 507
             ..|...:.:|..:.|..:|.|
Zfish   483 HTPKMIPQVVLRSLNGIHIKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	112/516 (22%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	110/508 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900