DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9h1 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	154/524 - (29%)
Similarity:	256/524 - (48%)	Gaps:	45/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALFIILL---VLLYKWSVAK-YDVFSERGVSHEKPWPLIGNI-PLKAMIGGMPVLKKMIELHTK 67
            :|:.|:||   :....|.|.: ::.:..||:.|::|....||. .|...:....:.|:.......
  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYNKLRN 65

  Fly    68 HTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRWKE 132
            .|..|..|.|.....:..|.|.:..|.:.|:|||.|.:....||. ::..||.:|:::...:||.
  Fly    66 KTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNE-RDDPLSANLVNIDGQKWKT 129

  Fly   133 MRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAF 197
            :|..|||.||..||:.|:..|.:..:|.:....|......|:   :|:.:...||..|||.:.||
  Fly   130 LRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDS---MEITNVVARFTADVIGSCAF 191

  Fly   198 GISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALF--PRLMKVLRIQVLDTKNIDYFSSLVT 260
            |:..:|......:|.::|  .:.|:.....|:|...||  |.|...||::....:..|::.:::.
  Fly   192 GLDCHSLSDPKAKFVQMG--TTAITERRHGKSMDLLLFGAPELAAKLRMKATVQEVEDFYMNIIR 254

  Fly   261 AAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIIS 325
            ..:.||.::.|.|.|.:.:|:|.|.:  .|..||.      :..|.:::.||..:||.||||..|
  Fly   255 DTVDYRVKNNVKRHDFVDMLIEMKLK--FDNGDKE------NGLTFNEIAAQAFIFFLAGFETSS 311

  Fly   326 SSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPSISTD 390
            :::.|..:||..:..:||:|..||.:|.::..|: |.||.:.:|.||:.|:.|.:||.|......
  Fly   312 TTMGFALYELACHQDIQDKLRTEINTVLKQHNGK-LDYDSMREMTYLEKVIDETMRKRPVVGHLI 375

  Fly   391 RECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGHALESR---VY 452
            |...|.   :.....| ::..||..:.:|..::|||||.:.:||.|.|||| |...::.|   .:
  Fly   376 RVATQH---YQHTNPK-YNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERF-DEDQVQQRPACTF 435

  Fly   453 MPFGVGPRNCIGNRMALMELKSIVYQLLLNFK--------LLPAKRTSRDLLNDIRGHGLKPKNG 509
            :|||.|||||||.|...|::...:..|:.|||        ::|.:..:.|.|       |..|.|
  Fly   436 LPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFL-------LSSKGG 493

  Fly   510 FWLK 513
            ..||
  Fly   494 IHLK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	143/487 (29%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	144/490 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.870