DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	150/542 - (27%)
Similarity:	262/542 - (48%)	Gaps:	61/542 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTK-- 67
            |:.|.|...|.::.|.|.......:...||.:.:|:|::| ...:.:...:|..:::.:.|..
  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVG-CTREFLTAKVPFFEQIQKFHEAPG 64

  Fly    68 HTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVN---HNSMHNNIQESILSKSLISLRDGR 129
            ....|..|:|........:||.||||.:.||:|.:|.|   ....||   :::..|:|...|...
  Fly    65 FENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHN---DALGYKNLFFARSPG 126

  Fly   130 WKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQD---ASIELEMKDYFTRFANDV 191
            |:|:|..::|.||..|::.||.|        ::.|.:.|:.|.:   :..|:::||..:||..|:
  Fly   127 WRELRTKISPVFTSGKIKQMYPL--------MVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDL 183

  Fly   192 IATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFS 256
            |||:|||:..|:.:...:|||...:|:..::....:...:..:.|.|..:.|:::...:...:..
  Fly   184 IATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIR 248

  Fly   257 SLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGF 321
            |.|...::.|:.....|.|:|.:|:..|::..|:....||      |...|.|:||..:|..|||
  Fly   249 SSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSK------EVDLDYLVAQAAVFQTAGF 307

  Fly   322 EIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPS 386
            |..:|::....:||..|..:||||.:||:....:  ...::|:::.:|.||..||.|.|||:|..
  Fly   308 ETSASTMTMTLYELAKNEALQDRLRQEIVDFFGD--EDHISYERIQEMPYLSQVVNETLRKYPIV 370

  Fly   387 ISTDRECRQDIDLFDENGQKLFSARKGDVLQIP--------IFSLHHDPENFEDPEFFNPERFAD 443
            ...:|||.|..:     |:: |:......:::|        ..::|.||:.:.|||.::||||..
  Fly   371 GYIERECSQPAE-----GER-FTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNS 429

  Fly   444 GHA--LESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKL---------------LPAKRT 491
            .:.  |....|||||||||||||.|:.|::.|..:..:|.|.:.               .|...:
  Fly   430 SNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMAS 494

  Fly   492 SRDLLNDIRGHGLKPKNGFWLK 513
            .||::  :|...:..|..|..|
  Fly   495 KRDII--LRVEKVSGKKDFGQK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	141/506 (28%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	138/494 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461058
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800