DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	130/571 - (22%)
Similarity:	234/571 - (40%)	Gaps:	105/571 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MIALALFIILLVLLYKWSVAKYDVFSERGVSHEK----------PWPLIGNIPLKAMIGGMP--V 57
            :..|||.::.|:.|         |:.||..|..:          |.|::||   ...||..|  :
  Fly     3 LAVLALLVLPLITL---------VYFERKASQRRQLLKEFNGPTPVPILGN---ANRIGKNPAEI 55

  Fly    58 LKKMIELHTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESI----- 117
            |....:.         :..|...:.:|::.....|.:...|:.::.:|...:   ||:|.
  Fly    56 LSTFFDW---------WYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQL---IQKSTIYDLL 108

  Fly   118 ---LSKSLISLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSE---EGVIHIQEQLELSQDASI 176
               |...|::....:|.:.|.::||:|       .::::|...|   |.......||:.:.....
  Fly   109 HPWLGHGLLTSFGSKWHKHRKMITPSF-------HFNILQDFHEVMNENSAKFMTQLKKASAGDT 166

  Fly   177 ELEMKDYFTRFANDVIATVAFGISINSFRRKDNEFFRIGQAMS---RISAWSVVKA--MLYALFP 236
            .::.:::......|||...|.|:.||:..::|:...:..:.|.   .:.|:...|.  .:::|.|
  Fly   167 IIDFQEHANYLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTP 231

  Fly   237 RLMKVLR-IQVLDTKNIDYFSSLVTAAMR--YRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDE 298
            ......: ::.|.....|.....|.|...  .:::|....|          ::::|.|.......
  Fly   232 EFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLP----------RKKMAFLDTLLSST 286

  Fly   299 LYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTY 363
            :.....|..::..:...|.|.|.:..:|.:.|..:.|..:|.||.:||.|...|......:.:::
  Fly   287 IDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSF 351

  Fly   364 DKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPE 428
            .::.||||||:.:.||.|.:|......|.|.:|.|:   ||.   ...||..|.:.:..|.::..
  Fly   352 QEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI---NGS---IVPKGTTLNLALILLGYNDR 410

  Fly   429 NFEDPEFFNPERFADGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPA--KRT 491
            .|:||..|.||||.:....... |:||..|||||||.:.||:|||:::.:::.:|::|||  :..
  Fly   411 IFKDPHHFRPERFEEEKPAPFE-YLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELV 474

  Fly   492 SRD-LLNDIRGHG-----------------------LKPKNGFWLKFEARQ 518
            |.| .||...|..                       ||..||..|:...|:
  Fly   475 STDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRLRERR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	119/530 (22%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	107/471 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810