DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	526	Identity:	156/526 - (29%)
Similarity:	276/526 - (52%)	Gaps:	48/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKH 68
            |:..|.|..|:|||||::....:.:|.::|:...||.|.:|.: |....|   :.|..:|.:.|:
Mouse     8 SLDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTV-LNYYTG---IWKFDMECYEKY 68

  Fly    69 TGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQE----SILSKSLISLRDGR 129
              ...:|::..:..:..:.|||.||.:.:|:.      .|:..|.:|    .|:||::...:|..
Mouse    69 --GKTWGLFDGQTPLLVITDPETIKNVLVKDC------LSVFTNRREFGPVGIMSKAISISKDEE 125

  Fly   130 WKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIAT 194
            ||..|.:|:|.||..:::.|:.:|:...:..|.:::::.|    ..:.:.|||....::.|||.:
Mouse   126 WKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAE----KGMPVAMKDVLGAYSMDVITS 186

  Fly   195 VAFGISINSFRRKDNEFFRIGQAMSRISAWS--VVKAMLYALFPRLMKVLRIQVLDTKNIDYFSS 257
            .:||::::|....::.|....:...|:..:.  :...:|:.|...:.::|.|.:....:|::|..
Mouse   187 TSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSIEFFKK 251

  Fly   258 LVTAAMRYR----QEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFF 318
            .|......|    |:|:|   |.:.|:|.:        .:.|||:..:..|:..::..|.::|..
Mouse   252 FVDRMQESRLDSNQKHRV---DFLQLMMNS--------HNNSKDKDSHKAFSNMEITVQSIIFIS 305

  Fly   319 AGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKW 383
            ||:|..||:|.|..:.|..:|.:|.:|..||...... |..| |.|.:.:|:|||||:.|.||.:
Mouse   306 AGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPN-KATP-TCDTVMEMEYLDMVLNETLRLY 368

  Fly   384 PPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGH--A 446
            |.....:|.|::|::|   ||..:   .||.::.||.::|||||:::.|||.|.||||:..:  :
Mouse   369 PIVTRLERVCKKDVEL---NGVYI---PKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGS 427

  Fly   447 LESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFW 511
            ::..||:|||:|||||||.|.|||.:|..|.::|.||...|.:.|...|....:|. |:|:....
Mouse   428 IDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGI-LQPEKPIV 491

  Fly   512 LKFEAR 517
            ||...|
Mouse   492 LKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	142/485 (29%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	143/490 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770