DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	128/525 - (24%)
Similarity:	250/525 - (47%)	Gaps:	50/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMI-----ELHTK 67
            |.|.:.||||:|.:....::.:.:||:.....||.:|:.|      .:...|:.|     :::.|
  Fly     8 LVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFP------SIFTRKRNIAYDIDDIYEK 66

  Fly    68 HTGSP-VYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNI----QESILSKSLISLRD 127
            :..:. :.|::..|.....|..||.|..|...:|..|  ||:...|.    .:.||..:...|..
  Fly    67 YKDTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSF--HNNEWRNFVNKKTDMILGNNPFVLTG 129

  Fly   128 GRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVI 192
            ..|||.|:.:.||.:.::::.:|.:.||..::.|.:|:.|.:::  .|..|:..|....:..:|:
  Fly   130 DEWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMA--TSEGLDAMDLSLCYTTEVV 192

  Fly   193 ATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFSS 257
            :....|:|..||........::.:.:...|...:..:::..|:.::.|...:...:.:...:|..
  Fly   193 SDCGLGVSAQSFTDTPTPLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLD 257

  Fly   258 LVTAAMRYRQEH-KVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGF 321
            ::...:..|.|. :..|.|.::.:::.::::               ....|::|...:.|...||
  Fly   258 IIRRCITLRLEKPEQQRDDFLNYMLQLQEKK---------------GLHTDNILINTMTFILDGF 307

  Fly   322 EIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPS 386
            |..:..|..:...|..||..||:       |.:|:....||:|:::::.:||..:.|.||.:.|.
  Fly   308 ETTALVLAHIMLMLGRNPEEQDK-------VRKEIGSADLTFDQMSELPHLDACIYETLRLFSPQ 365

  Fly   387 ISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERF--ADGHALES 449
            ::..:...:..:..::||:.: ..:.|||:.||:.:|||||:.:|||..|.||||  ::|..::|
  Fly   366 VAARKLVTEPFEFANKNGRTV-HLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKS 429

  Fly   450 ----RVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGF 510
                .||:.||.|||:|.|.|.||.:||:.:.::|.||::....:|..|...|........|.|.
  Fly   430 YRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGGI 494

  Fly   511 WLKFE 515
            :|.|:
  Fly   495 YLDFK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	117/490 (24%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	112/469 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460896
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900