DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	139/531 - (26%)
Similarity:	242/531 - (45%)	Gaps:	68/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMI---GGMPVLKKMIELHTKHTGSPVYG 75
            ||..:|.:.|:.:..:..|||:..:..||.|:.|  .||   ....:..:.|.:|.::|.|.| |
  Fly    12 LLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFP--NMIWPRQHFTMDMRDIYMHYRNTHSYV-G 73

  Fly    76 IYALRDAVFFVRDPELIKLIGIKEFDHFVNHNS--MHNNIQESILSKSLISLRDGRWKEMRNILT 138
            .|.||.....|.:|.|:..|.:..|.||.|:::  |.:..::.:::.:...|....|:..|.:.:
  Fly    74 CYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQRAVFS 138

  Fly   139 PAFTGSKMRIMYDLIQS-CSEEGVIHIQEQLELSQDASI------ELEMKDYFTRFANDVIATVA 196
            ...|..::|..:.::|. |           |:|.|..:|      :|:..|...||..:.:....
  Fly   139 TLLTNGRIRTTHAIMQRVC-----------LDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCV 192

  Fly   197 FGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLVTA 261
            .||...:|........|....||..:....:...::.|||.|.:.||.:|....:..::..:::.
  Fly   193 LGIQARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMISE 257

  Fly   262 AMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISS 326
            |:|.|:.....|.|.|:.|:|  .||..|||:             :|:.:..:.|.|.|.:..|:
  Fly   258 ALRLRRSKHQERNDFINHLLE--MQRELDLSE-------------EDMASHAMTFMFDGLDTTSN 307

  Fly   327 SLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTY----DKLTKMKYLDMVVLEALRKWPPSI 387
            |:......|..||..|.|||||:..|:      |..|    |.|..:.||.....|:||.:|...
  Fly   308 SIAHCLLLLGRNPDCQRRLYEELQLVN------PGGYLPDLDALIDLPYLSACFNESLRIYPAGG 366

  Fly   388 STDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADG---HALES 449
            ...:.|.::.:|...:..:....|.||.:.:||::||:||:.:.:|:.|.||||.||   :..:.
  Fly   367 WASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQ 431

  Fly   450 RVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKP-------K 507
            .:::.||.|||.|:|.|:.|...|:.:..::..|:::.:.||       :.|..|.|       |
  Fly   432 GIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRT-------LNGTELDPLIFVGVHK 489

  Fly   508 NGFWLKFEARQ 518
            .|.||:|..|:
  Fly   490 GGIWLQFVPRK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	128/499 (26%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	126/493 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460878
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900