DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9h1 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	120/464 - (25%)
Similarity:	198/464 - (42%)	Gaps:	89/464 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DPELIKLI---------GIKEFDHFVNHNSMHNNIQESILSKS---LISLRDGRWKEMRNILTPA 140
            ||:.:|::         ||.:|            :...|:|.:   |:.|...:|.:...:||||
  Rat    98 DPDYVKVVLGRSDPKASGIYQF------------LAPWIVSGTGYGLLLLNGKKWFQHWRMLTPA 150

  Fly   141 F----TGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFG--- 198
            |    ....::||.|        .|..:.::.|...|....||:..|.:....|.:...||.
  Rat   151 FHYGILKPYVKIMAD--------SVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQG 207

  Fly   199 -----ISINSFRRKDNE-----FFRIGQAMSRISAWSVVKAMLYALFP--RLMKVLRIQVLDTKN 251
                 ::..|:.:...:     |||:..|.       ...:::|.:..  ||.:  |...:..::
  Rat   208 SVQLDVNSRSYTKAVEDLNNLTFFRVRSAF-------YGNSIIYNMSSDGRLSR--RACQIAHEH 263

  Fly   252 IDYFSSLVTAAMRYRQEHKVVRP----DMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQ 312
            .|....:..|.::..:|.:..|.    |.:.:|:.||.:....|||             :||.|:
  Rat   264 TDGVIKMRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSD-------------EDLRAE 315

  Fly   313 CLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVL 377
            ...|.|.|.:..:|.:.::.:.|..:|..|:|..||:.|:..:  |..:|:|.|.::.|..|.:.
  Rat   316 VDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGD--GTSVTWDHLDQISYTTMCIK 378

  Fly   378 EALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFA 442
            ||||.:||..|..||....:...|..     |..||....|.|:.|||:|..:.:|:.|:|.||:
  Rat   379 EALRLYPPVPSVSRELSSPVTFPDGR-----SIPKGITTTILIYGLHHNPSYWPNPKVFDPSRFS 438

  Fly   443 DGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLP-AKRTSRDLLNDIRGHGLKP 506
            ......|..|:||..|.|||||.:.|:.|||..|...||.|:||| ..|....:...:    ||.
  Rat   439 PDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMARLV----LKS 499

  Fly   507 KNGFWLKFE 515
            |||..|:.:
  Rat   500 KNGIHLRLK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	119/459 (26%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	119/460 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900