DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	136/553 - (24%)
Similarity:	244/553 - (44%)	Gaps:	98/553 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MIALALFIILLVLLYKWS----VAKYDVFSERGVSHEKPWPLIGNI-PLKAMIGGMPVLKKM--- 61
            ::..|.:|:..:|.:.:|    .::...|.:   |.::.| .:|:: .:::...||.::.:|
  Rat    23 LLGAASWILARILAWTYSFCENCSRLRCFPQ---SPKRNW-FLGHLGTIQSNEEGMRLVTEMGQT 83

  Fly    62 -IELHTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKE--FDHFVNHNSMHNNIQESILSKSLI 123
             .::|....| ||..:..|.|..|.....:...|:..|:  |..|:          :..|...|.
  Rat    84 FRDIHLCWLG-PVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFL----------KPWLGDGLF 137

  Fly   124 SLRDGRWKEMRNILTPAFTGSKMRIMYDLI--------QSCSEEGVIHIQEQLELSQDASIELEM 180
            .....:|...|.:|||||       .:|::        ||.:   ::|.:.: .|..:.|..|||
  Rat   138 LSSGDKWSRHRRLLTPAF-------HFDILKPYVKIFNQSVN---IMHAKWK-HLCLEGSARLEM 191

  Fly   181 KDYFTRFANDVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQ 245
            .:..:....|.:....||...|. :...:|:.   .|:..:|:..:.::....|:   :..|..:
  Rat   192 FENISLMTLDSLQKCLFGFDSNC-QESPSEYI---SAILELSSLIIKRSQQLFLY---LDFLYYR 249

  Fly   246 VLD----TKNIDYFSSLVTAAMRYRQ----------------EHKVVRPDMIHLLMEAKQQRLAD 290
            ..|    .|..|...:...|.:|.|:                :.|....|.|.:|:.||.:...:
  Rat   250 TADGRRFRKACDLVHNFTDAVIRERRRLLSSQGTDEFLESKTKSKSKTLDFIDVLLLAKDEHGKE 314

  Fly   291 LSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEE 355
            |||             :|:.|:...|.|.|.:..:|:|.::.:.|..:|..|:|..:|:..:..:
  Rat   315 LSD-------------EDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRD 366

  Fly   356 LKGQPLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPI 420
            .:.:.:.:|.|.::.:|.|.:.|:||..||:|...|.|.|||.|.|  |:.:   .||::..|.|
  Rat   367 REPEEIEWDDLAQLPFLTMCIKESLRLHPPAIDLLRRCTQDIVLPD--GRVI---PKGNICVISI 426

  Fly   421 FSLHHDPENFEDPEFFNPERFADGHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQLLLN 482
            |.:||:|..:.|||.|:|.|| |....:.|   .::||..|||||||...|:.|:|.:|...||.
  Rat   427 FGIHHNPSVWPDPEVFDPFRF-DSENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLR 490

  Fly   483 FKLLPAKRTSRDLLNDIRGHGLKPKNGFWLKFE 515
            |::||..:..|.....|    |:.:.|.||:.|
  Rat   491 FRVLPDDKEPRRKPEII----LRAEGGLWLRME 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	127/511 (25%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	128/519 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900