DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	552	Identity:	134/552 - (24%)
Similarity:	241/552 - (43%)	Gaps:	89/552 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKA----MIG--------GMP 56
            |.::||...::|.||            :|..|:.:.|..:..||..|    ::|        |..
Human    20 SALSLAGASLVLSLL------------QRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGRE 72

  Fly    57 VLKKMIELHTKHTGSPVYGIY---ALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESIL 118
            ..:::||...::...|:..::   ....|::...:.|:| |...|:.|    .:||:..: |..|
Human    73 FFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVI-LTSSKQID----KSSMYKFL-EPWL 131

  Fly   119 SKSLISLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQE-QLELSQDASIELEMKD 182
            ...|::....:|:..|.:|||.|   ...|:.|.:...:|:..|.::: :..::|:|   .....
Human   132 GLGLLTSTGNKWRSRRKMLTPTF---HFTILEDFLDIMNEQANILVKKLEKHINQEA---FNCFF 190

  Fly   183 YFTRFANDVIATVAFGISINSFRRKDNEFFRIGQAMSR------------ISAWSVVKAMLYALF 235
            |.|..|.|:|...|.|.:|.:....|:|:.|....||.            :..|       |.:|
Human   191 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLW-------YLMF 248

  Fly   236 PRLMKVLR-IQVLDTKNIDYFSSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQR-----LADLSDK 294
            ....:..: :|:|.|    :.:|::.........::..|.|.........::|     |..::|.
Human   249 KEGWEHKKSLQILHT----FTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDD 309

  Fly   295 SKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ 359
            ..:.|.:     :|:..:...|.|.|.:..::::.:..:.|..||.||.::..|:..|..: ..:
Human   310 EGNRLSH-----EDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGK-SDR 368

  Fly   360 PLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLH 424
            |.|.:.|.|::||:.|:.|.||.:|......|...:|.::..      :...||....|..::||
Human   369 PATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAG------YRVLKGTEAVIIPYALH 427

  Fly   425 HDPENFEDPEFFNPERFADGHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKL- 485
            .||..|.:||.|.||||...:| :.|   .|:||..|||||||.:.|:||.|:|:..:|.:|.:
Human   428 RDPRYFPNPEEFQPERFFPENA-QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491

  Fly   486 LPAKRTSRDLLNDIRGHGLKPKNGFWLKFEAR 517
            ...||....|...:.   |:|.||.|:|.:.|
Human   492 SNQKREELGLEGQLI---LRPSNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	123/511 (24%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	120/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810