DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9h1 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	141/496 - (28%)
Similarity:	256/496 - (51%)	Gaps:	41/496 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IALALFIIL---LVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTK 67
            :::..:::|   |:|.|.:....:.:|.:.|:...||.||.|.|    ...|..:.|...:.:.|
  Rat     7 LSIETWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTI----FNYGDGMWKFDDDCYKK 67

  Fly    68 HTGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWK 131
            :  ..::|.|........:.|||:||::.:|| :..|.|.....   ....:.|::....|..||
  Rat    68 Y--GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFG---PMGFMKKAITMSEDEEWK 127

  Fly   132 EMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVA 196
            .:|.||:|.||..|::.|:.|::...:.    :.:.|...:.....:.|||.|..::.|||...:
  Rat   128 RLRTILSPTFTSGKLKEMFPLMRQYGDT----LLKNLRREEAKGEPINMKDIFGAYSMDVITGTS 188

  Fly   197 FGISINSFRRKDNEFFRIGQAMSRISAWS--VVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLV 259
            ||::::|.....:.|.:..:.:.:...:.  ::..:|:.....:.::|...:...:::::|...|
  Rat   189 FGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFV 253

  Fly   260 TAAMRYR-QEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEI 323
            ....:.| ..::..|.|.:.|:|..:..: ...|.|:..:|        ::.||.::|.|.|::.
  Rat   254 KTMKKNRLDSNQKSRVDFLQLMMNTQNSK-GQESQKALSDL--------EMAAQAIIFIFGGYDA 309

  Fly   324 ISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPPSI 387
            .|:|:.|:.:||...|.||.:|..||   ...|..: |:|||.|.:|:||||||.|:||.:|.:.
  Rat   310 TSTSISFIMYELATRPNVQKKLQNEI---DRALPNKAPVTYDALMEMEYLDMVVNESLRLYPIAT 371

  Fly   388 STDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGH--ALESR 450
            ..||..::|:::   ||..:   .||.|:.|||:.||.:||.:.:||.||||||:..:  :::..
  Rat   372 RLDRVSKKDVEI---NGVFI---PKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPY 430

  Fly   451 VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRT 491
            ||:|||.|||||||.|.||:.:|..|..:|.||.:.|.::|
  Rat   431 VYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	135/461 (29%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	127/432 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770