DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	156/528 - (29%)
Similarity:	253/528 - (47%)	Gaps:	59/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKHTGS- 71
            |.|...||..|..:...::..:..||:...:|..|.|:......:....:|:   |.:....||
  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQ---ETYDAFRGSA 66

  Fly    72 PVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMRNI 136
            .|.|.|.....:..|.|.:|:|.:.|::|::||:..|.|.:    .|:.:|.:|:...|:.:|..
  Fly    67 KVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGD----PLTANLFNLQGEEWRNLRTK 127

  Fly   137 LTPAFTGSKMRIMYDLIQSCSEE--GVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGI 199
            |:|.||..||:.|:..:.:.:::  |..   ::|..||.|.:||.  |...|:..|||.:.|||.
  Fly   128 LSPTFTSGKMKYMFGTVSTVAQQLGGTF---DELVGSQGAVLELH--DLMARYTTDVIGSCAFGT 187

  Fly   200 SINSFRRKDNEFFRIGQAMSRIS----AWSVVKAMLYALFPRLMKV-LRIQVLDTKNIDYFSSLV 259
            ..:|.|....||.::|:.:.|.|    .|.:.| |.|  ...|.|: |.:::|......:|:.:|
  Fly   188 ECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFK-MTY--LSSLAKLGLPVRILHPDITKFFNRIV 249

  Fly   260 TAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEII 324
            ...:..|:...:.|.|.:.||::.::|      :..|.      .|.:.:.||..:||.||||..
  Fly   250 RETVELRERENIRRNDFMDLLLDLRRQ------ENGKG------LTMEQMAAQAFVFFVAGFETS 302

  Fly   325 SSSLCFLTHELCLNPTVQDRLYEEI---ISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPS 386
            ||::.:...||..|..||.:|..||   |..|.:     |||:.:.:|.|||..:.|.|||:|..
  Fly   303 SSNMSYALFELAKNQDVQQKLRMEINDSIGKHGK-----LTYEAMMEMPYLDQTITETLRKYPAL 362

  Fly   387 ISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGHALESR- 450
            .|..|...:|.::...:|.......||..:.||:.::|:|||.:.:|..|.|||||.....|..
  Fly   363 SSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHP 427

  Fly   451 -VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKL-LP------AKRTSRDLLNDIRGHGLKPK 507
             .::.||.|||||||.|...|::|..:..||..|:. ||      .|.|.|:|:       |.|.
  Fly   428 TAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLI-------LLPS 485

  Fly   508 NGFWLKFE 515
            :|..|:.:
  Fly   486 DGVRLQVD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	148/493 (30%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	149/498 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970