DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	162/532 - (30%)
Similarity:	271/532 - (50%)	Gaps:	61/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIEL---- 64
            ||....|.:|.|||||.:....:.:|.:.|:...||.|.:|.|        :...|...|.
  Rat     8 SMETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTI--------LAYRKGFWEFDKYC 64

  Fly    65 HTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDG 128
            |.|:  ..::|:|..|..|..:.||::||.:.:|| :..|.|.   .|.....||.|::....|.
  Rat    65 HKKY--GKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNR---RNFGPVGILKKAISISEDE 124

  Fly   129 RWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIA 193
            .||.:|.:|:|.||..|::.|:.:|...::..|.::::..|..:..|    |||.|..::.|||.
  Rat   125 EWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTS----MKDIFGAYSMDVIT 185

  Fly   194 TVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYA--LFP---RLMKVLRIQVLDTKNID 253
            ..:||::::|.....:.|.   :.:.::..:.:...:..:  |||   .|.:.|.:.:.....||
  Rat   186 ATSFGVNVDSLNNPQDPFV---EKIKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVID 247

  Fly   254 YFSSLVTAAMRYR-QEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFF 317
            :|.:.|......| :|.:..|.|.:.|::.::..::.| |.|:..::        :::||.::|.
  Rat   248 FFKTSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKD-SHKALSDV--------EIVAQSVIFI 303

  Fly   318 FAGFEIISSSLCFLTHELCLNPTVQDRLYEEIIS-----VHEELKGQPLTYDKLTKMKYLDMVVL 377
            |||:|..||:|.|:.:.|.::|.:|.:|.:||.:     .|       .|||.|.:|:||||||.
  Rat   304 FAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAH-------ATYDTLLQMEYLDMVVN 361

  Fly   378 EALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFA 442
            |.||.:|.:...:|.|:.|:::   ||..:   .||.|:.||.|:||.||..:.:||.|.||||:
  Rat   362 ETLRLYPIAGRLERVCKTDVEI---NGVFI---PKGTVVMIPTFALHKDPHYWPEPEEFRPERFS 420

  Fly   443 DGHA--LESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLK 505
            ..:.  :...:|:|||.|||||||.|.|||.:|..:.::|.||...|.|.|...|....:|. |:
  Rat   421 KKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGL-LQ 484

  Fly   506 PKNGFWLKFEAR 517
            |:....||..:|
  Rat   485 PEKPLLLKVVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	148/491 (30%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	149/496 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770