DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9h1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	551	Identity:	129/551 - (23%)
Similarity:	229/551 - (41%)	Gaps:	113/551 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIE-----------LHTK 67
            :|..:..|..|.||..|......:.|.|       ....|.:.::|...|           .|..
Mouse    30 ILARILAWIYAFYDNCSRLRCFPQPPKP-------SWFWGHLALMKNNEESMQFITHLGHDFHDV 87

  Fly    68 HTG--SPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRW 130
            |..  .|||.|..|....|.....:....:..||.       :::..::..:....|:|..| :|
Mouse    88 HLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEM-------TLYGFLKPWLGDGLLMSAGD-KW 144

  Fly   131 KEMRNILTPAFTGSKMRIMYDLIQSC-----SEEGVIHIQEQLELSQDASIELEMKDYFTRFAND 190
            ...|.:|||||       .:|:::|.     ....::|.:.|...|:..| .|:|.::.:....|
Mouse   145 SHHRRLLTPAF-------HFDILKSYVKIFNKSVNIMHAKWQCLASKGTS-RLDMFEHISLMTLD 201

  Fly   191 VIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKA---------MLYAL------FPRLMK 240
            .:....|.:..|. :..|:::......:|.:    |||.         :||.|      |.:...
Mouse   202 SLQKCIFSVDSNC-QESDSKYIAAILELSSL----VVKRHRQPFLYLDLLYYLTADGRRFRKACD 261

  Fly   241 VL----------RIQVLDTKNIDYFSSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKS 295
            ::          |...|:|:.:::.          :.:.|....|.|.:|:.|:.:....||:
Mouse   262 LVHNFTDAVIKERRSTLNTQGVEFL----------KAKAKTKTLDFIDVLLMAEDEHGKGLSN-- 314

  Fly   296 KDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQP 360
                       :|:.|:...|.|.|.:..:|:|.::.:.|..:|..|:|..:|:..:..:...:.
Mouse   315 -----------EDIRAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEE 368

  Fly   361 LTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHH 425
            :.:|.|.::.:|.|.:.|:||..||.:...|.|.||:.|.|  |:.:   .||::..|.||.:||
Mouse   369 IEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPD--GRAI---PKGNICVISIFGVHH 428

  Fly   426 DPENFEDPEFFNPERFADGHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLP 487
            :|..:.|||.:||.|| |....:.|   .::||..|.|||||...|:.|:|..:...||.|::||
Mouse   429 NPSVWPDPEVYNPFRF-DPENPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRILP 492

  Fly   488 AKRTSR---DLLNDIRGHGLKPKNGFWLKFE 515
            ..:..|   :|:       |:.:.|.||:.|
Mouse   493 DDKEPRRKPELI-------LRAEGGLWLRVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	120/522 (23%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	120/524 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900