DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9h1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	159/512 - (31%)
Similarity:	258/512 - (50%)	Gaps:	52/512 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKHTGSPVY 74
            |...:|||||.:..:.:..|.:.|:|..||.|.:|||  .|...|.....:  ..|.|:  ..::
  Rat    14 LLATILVLLYLYGTSTHGNFKKLGISGPKPLPFVGNI--LAYRHGFWEFDR--HCHKKY--GDIW 72

  Fly    75 GIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMRNILT 138
            |.|..|..:..:.||::||.:.:|| :..|.|..|..   ...||.|::....|..||.:|.:|:
  Rat    73 GFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFG---PAGILKKAITLSEDEEWKRLRTLLS 134

  Fly   139 PAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGISINS 203
            |.||..|::.|:.:|...::..|.:::.:.|...    .:.|||.|..::.|||...:||::::|
  Rat   135 PTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGN----PITMKDIFGAYSMDVITGTSFGVNVDS 195

  Fly   204 FRRKDNEFFRIGQAMSRISAWSVVKAMLYA--LFPRLMKVLR---IQVLDTKNIDYFSSLVTAAM 263
            .....|.|.   |.:.::..::.:.....:  |||.|..|..   |.|.....:.:|.:.|....
  Rat   196 LNNPQNPFV---QKVKKLLKFNFLDPFFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMK 257

  Fly   264 RYRQEHKV-VRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSS 327
            ..|.:.|| .|.|.:.|::.         |..|.|:..:...|..:::||.:.|.|||:|..||:
  Rat   258 ENRMQEKVKQRLDFLQLMIN---------SQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSA 313

  Fly   328 LCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPPSISTDR 391
            |.|..:.|..:|.:|.:|.:||.:.   |..: |:|||.|.:|:|||||:.|.||.:|.....:|
  Rat   314 LSFALYLLATHPDLQKKLQDEIDAA---LPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLER 375

  Fly   392 ECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERF--ADGHALESRVYMP 454
            .|::|:::   ||..:   .||.|:.:|.|:||.||:.:.:||.|.||||  .:..::...:|:|
  Rat   376 VCKKDVEI---NGVFI---PKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLP 434

  Fly   455 FGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFW 511
            ||.|||||||.|.|||.:|..:.::|.||.....|.|...|  .:|      |.||:
  Rat   435 FGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPL--KLR------KKGFF 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	150/484 (31%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	151/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770