Protein Alignment Cyp9h1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 155/526 - (29%)
• Similarity: 266/526 - (50%)
• Gaps: 61/526 - (11%)

  Fly    10 LFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKM----IELHTKHTG 70
            |..:.|:|||.:....:.:|.:.|:....|.|.:||        .:...|..    :|.:.|:
Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN--------ALSFRKGYWTFDMECYKKY-- 68

  Fly    71 SPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMR 134
            ..|:|||..:..:..:.||::||.:.:|| :..|.|.....   ....:..::....|..||.:|
Human    69 RKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG---PVGFMKNAISIAEDEEWKRIR 130

  Fly   135 NILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGI 199
            ::|:|.||..|::.|..:|....:..|.:::.:.|..:..:    :|..|..::.|||.:.:||:
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT----LKHVFGAYSMDVITSTSFGV 191

  Fly   200 SINSFRRKDNEFFRIGQAMSRISAWS--VVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLV--- 259
            ||:|.....:.|....:.:.|.:...  |:...::.....:::.|.|.|...|.|.:.:..|
Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQI 256

  Fly   260 -TAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEI 323
             ...::..|:|:|   |.:.|:::         |..|||...:...:..:|:||.::|.|||:|.
Human   257 KEGRLKETQKHRV---DFLQLMID---------SQNSKDSETHKALSDLELMAQSIIFIFAGYET 309

  Fly   324 ISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPPSI 387
            .||.|.|:.:||..:|.||.::.:||.:|   |..: |.|||.:.:::||||||.|.||.:|.::
Human   310 TSSVLSFIIYELATHPDVQQKVQKEIDTV---LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAM 371

  Fly   388 STDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGHA--LESR 450
            ..:|.|::|:::   ||..:   .||.|:.||.:.|||||:.:.:||.|.||||:..:.  ::..
Human   372 RLERVCKKDVEI---NGMFI---PKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430

  Fly   451 VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGL----KPKNGFW 511
            :|.|||.|||||||.|.||:.:|..:.::|.||...|.|.|...|  .:|..||    ||   ..
Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL--KLRFGGLLLTEKP---IV 490

  Fly   512 LKFEAR 517
            ||.|:|
Human   491 LKAESR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	CYP6-like	69..511	CDD:410679	137/455 (30%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	138/459 (30%)