DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9h1 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	533	Identity:	164/533 - (30%)
Similarity:	285/533 - (53%)	Gaps:	59/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMIALALFIIL---LVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELH 65
            |.::|..:::|   |||||::...|:::|.::|:...||.|.:|.: |....|   :.|..:|.:
Mouse     5 SALSLETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTV-LNYYKG---LWKFDMECY 65

  Fly    66 TKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGR 129
            .|:  ...:|::..:..:..|.|||.||.:.:|| |..|.|.....   ...|:||::...:|..
Mouse    66 KKY--GKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFG---PVGIMSKAISISKDDE 125

  Fly   130 WKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIAT 194
            ||..|.:|:|.||..|::.|:.:|:...:..|.:::::.:..:..:    |||....::.|||.:
Mouse   126 WKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVT----MKDVLGAYSMDVITS 186

  Fly   195 VAFGISINSFRRKDNEFFRIGQAMSRIS-----AWSVVKAMLYALFPRLMKV---LRIQVLDTKN 251
            .:||::::|....::.|....:.:.|..     .:|||      |||.|..|   |.|.:....:
Mouse   187 TSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVV------LFPFLTPVYEMLNICMFPKDS 245

  Fly   252 IDYFSSLV----TAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQ 312
            |::|...|    .:.:..:|:|:|   |.:.|:|.:        .:.|||::.:...:..::.||
Mouse   246 IEFFKKFVDRMKESRLDSKQKHRV---DFLQLMMNS--------HNNSKDKVSHKALSDMEITAQ 299

  Fly   313 CLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVV 376
            .::|.|||:|..||:|.|..|.|..:|.:|.:|.:||   .|.|..: |.|||.:.:|:|||||:
Mouse   300 SIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEI---DEALPNKAPPTYDTVMEMEYLDMVL 361

  Fly   377 LEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERF 441
            .|.||.:|.:...:|.|::|::|   ||..:   .||..:.||.::|||||:::.:||.|.||||
Mouse   362 NETLRLYPIANRLERVCKKDVEL---NGVYI---PKGSTVMIPSYALHHDPQHWSEPEEFQPERF 420

  Fly   442 ADGH--ALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGL 504
            :..:  :::..||:|||.|||||:|.|.|||.:|..:.:::.||...|.|.|...|....:|. |
Mouse   421 SKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL-L 484

  Fly   505 KPKNGFWLKFEAR 517
            :|:....||...|
Mouse   485 QPEKPIVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	150/489 (31%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	151/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770