DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9h1 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	526	Identity:	155/526 - (29%)
Similarity:	266/526 - (50%)	Gaps:	61/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKM----IELHTKHTG 70
            |..:.|:|||.:....:.:|.:.|:....|.|.:||        .:...|..    :|.:.|:
Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN--------ALSFRKGYWTFDMECYKKY-- 68

  Fly    71 SPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMR 134
            ..|:|||..:..:..:.||::||.:.:|| :..|.|.....   ....:..::....|..||.:|
Human    69 RKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG---PVGFMKNAISIAEDEEWKRIR 130

  Fly   135 NILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGI 199
            ::|:|.||..|::.|..:|....:..|.:::.:.|..:..:    :|..|..::.|||.:.:||:
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT----LKHVFGAYSMDVITSTSFGV 191

  Fly   200 SINSFRRKDNEFFRIGQAMSRISAWS--VVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLV--- 259
            ||:|.....:.|....:.:.|.:...  |:...::.....:::.|.|.|...|.|.:.:..|
Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQI 256

  Fly   260 -TAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEI 323
             ...::..|:|:|   |.:.|:::         |..|||...:...:..:|:||.::|.|||:|.
Human   257 KEGRLKETQKHRV---DFLQLMID---------SQNSKDSETHKALSDLELMAQSIIFIFAGYET 309

  Fly   324 ISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPPSI 387
            .||.|.|:.:||..:|.||.::.:||.:|   |..: |.|||.:.:::||||||.|.||.:|.::
Human   310 TSSVLSFIIYELATHPDVQQKVQKEIDTV---LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAM 371

  Fly   388 STDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGHA--LESR 450
            ..:|.|::|:::   ||..:   .||.|:.||.:.|||||:.:.:||.|.||||:..:.  ::..
Human   372 RLERVCKKDVEI---NGMFI---PKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430

  Fly   451 VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGL----KPKNGFW 511
            :|.|||.|||||||.|.||:.:|..:.::|.||...|.|.|...|  .:|..||    ||   ..
Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL--KLRFGGLLLTEKP---IV 490

  Fly   512 LKFEAR 517
            ||.|:|
Human   491 LKAESR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	144/491 (29%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	144/495 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770