DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and Angpt2

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_604449.1	Gene:	Angpt2 / 89805	RGDID:	621861	Length:	496	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	127/458 - (27%)
Similarity:	211/458 - (46%)	Gaps:	85/458 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 EQIHQLQLAQRNLRRQVNGLR--FHHIDERVRS--IEVEQHRIANANFNLSSQIASLDKLHTSML 388
            :.:.:||:.:..|......|.  .::|.:.::.  :|::|:.:.|       |.|.:.::.||:|
  Rat    75 DSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQN-------QTAVMIEIGTSLL 132

  Fly   389 -------ELLEDVE----GLQTKMDKSIPELRHEIS--KLEFANAQITSEQSLIREEGTNAARSL 440
                   ..|.|||    ...|:::..:  |:|.||  |||......|||.:.::::.:...:.:
  Rat   133 NQTAAQTRKLTDVEAQVLNQTTRLELQL--LQHSISTNKLEKQILDQTSEINKLQDKNSFLEKKV 195

  Fly   441 QAMAVSVSV-LQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQ 504
            ..|....|| ||..:|       ..|||:..|.: ||.|.||::.||.....       .|...|
  Rat   196 LDMEDKHSVQLQSMKE-------QKDQLQVLVSK-QSSVIDELEKKLVTATV-------NNSVLQ 245

  Fly   505 MPQDDSPIDSVLAETLVSELENVET-QYEAIINKLP-------HDCSEVHTQ---TDGLHLIAPA 558
            ..|.|      |.||:.|.|..:.: .|::.: .:|       .||:|:...   |.|::.:...
  Rat   246 KQQHD------LMETVNSLLTMMSSPDYKSSV-AVPKEEKTTFRDCAEIFKSGLTTSGIYTLTFP 303

  Fly   559 GQRHPLMTHCTAD----GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNC 619
            .....:..:|..|    |||.:|.|.|||.||.|:|.:|.:|||:|.||:|:|||.:..||..:.
  Rat   304 NSTEEVKAYCDMDMGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNEFVSQLTSGHR 368

  Fly   620 SRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQ-GMQFSAIDDDRDIS 683
            ..|::|::|...:...:.|:.||:|.....||:|:...:|.|....:..| |..||..|.|.|..
  Rat   369 YVLKIQLKDWEGSEAHSLYEHFYLSGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKC 433

  Fly   684 QTHCAANYEGGWWFSHCQHANLNGRY-----NL----GLTWFDAARNEW----IAVKSSRMLVKR 735
            ...|:....|||||..|..:||||:|     |.    |:.|:     .|    .::|::.|:::
  Rat   434 ICKCSQMLTGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWY-----YWKGSGYSLKATTMMIR- 492

  Fly   736 LPA 738
             ||
  Rat   493 -PA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	70/225 (31%)
Angpt2	NP_604449.1	Mplasa_alph_rch	<78..>232	CDD:275316	43/170 (25%)
Angpt2	NP_604449.1	FBG	280..494	CDD:214548	69/220 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910