DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and SMC1

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_116647.1	Gene:	SMC1 / 850540	SGDID:	S000001886	Length:	1225	Species:	Saccharomyces cerevisiae

Alignment Length:	635	Identity:	130/635 - (20%)
Similarity:	234/635 - (36%)	Gaps:	187/635 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SVAFVSGAASGGV------------VLSDVNNMLRDAKVVTSEKP-VVHSKQETEAPESSVELLR 96
            :::||.|..|..:            ||:|.|:...|.:...|..| ..:.|...:.....|||:|
Yeast    45 AISFVLGVRSNHLRSNILKDLIYRGVLNDENSDDYDNEGAASSNPQSAYVKAFYQKGNKLVELMR 109

  Fly    97 FVDDDEDSEDISSIERQDGRTMESKKMA---DQVRLLTKQLNALM-------------------- 138
            .:..:.|:.     .:.||:|:..|..:   :...:|.|..|.|:
Yeast   110 IISRNGDTS-----YKIDGKTVSYKDYSIFLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMF 169

  Fly   139 ------LRRREDYEMLEHNLRKSLRLTT--------------------NANS---VDADMRSEL- 173
                  ::.:::||.|:..:.|..:..|                    |.|.   ...|.::||
Yeast   170 EEVSGSIQYKKEYEELKEKIEKLSKSATESIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQ 234

  Fly   174 ---------------NQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVAQD 223
                           .:|.::|:||.|..|..|            .:|..::..|||:.|:..::
Yeast   235 KFQALWQLYHLEQQKEELTDKLSALNSEISSLK------------GKINNEMKSLQRSKSSFVKE 287

  Fly   224 ----VQQRSS---TFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALV 281
                .:|:|.   .|:|...:.||.:.:|:...|..:|....|..::.|::::.:|:...:....
Yeast   288 SAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISHIEKRIESLQKDLQRQKTYVERFET 352

  Fly   282 KLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQ----------SEQIHQLQLA 336
            :|:..||   |..:.|||......|.::..|... |.|..:|..:          .|:|..|...
Yeast   353 QLKVVTR---SKEAFEEEIKQSARNYDKFKLNEN-DLKTYNCLHEKYLTEGGSILEEKIAVLNND 413

  Fly   337 QRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLEL---LEDVEGLQ 398
            :|.::.::.  ||:      :..::.:.||..   .||   .:.:||.|.:.:|   |.:...|.
Yeast   414 KREIQEELE--RFN------KRADISKRRITE---ELS---ITGEKLDTQLNDLRVSLNEKNALH 464

  Fly   399 TKMDKSIPELRHEISKL----EFANAQ-----ITSEQSLIREEGTNAARSLQAMAVSVSVLQEER 454
            |       |..||:.||    |.||.|     ....::|::.:..:|               .:|
Yeast   465 T-------ERLHELKKLQSDIESANNQEYDLNFKLRETLVKIDDLSA---------------NQR 507

  Fly   455 EGM--RKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLA 517
            |.|  |||..|:..|:.....::.||:|     |.|   |.|..:...|...:.::   .|||:.
Yeast   508 ETMKERKLRENIAMLKRFFPGVKGLVHD-----LCH---PKKEKYGLAVSTILGKN---FDSVIV 561

  Fly   518 ETLVSELENV---ETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQRHPL 564
            |.|....|.:   :.|.....:.:|.|..|....|    |..|..|.:.|
Yeast   562 ENLTVAQECIAFLKKQRAGTASFIPLDTIETELPT----LSLPDSQDYIL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	23/106 (22%)
sca	NP_476710.2	FBG	538..736	CDD:214548	8/27 (30%)
SMC1	NP_116647.1	Smc	3..1225	CDD:224117	130/635 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000