DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sca and Fgl2

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_445907.2	Gene:	Fgl2 / 84586	RGDID:	620170	Length:	429	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	110/433 - (25%)
Similarity:	180/433 - (41%)	Gaps:	90/433 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 EQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQ 426
            |:|.:.....:.|:|.|...:|..|     ...||.|.....::|.|..::.:      |..|.:
  Rat    21 EKHNLTEGLEDASAQAACPARLEGS-----GRCEGSQCPFQLTLPTLTLQLPQ------QFGSME 74

  Fly   427 SLIREEGT--NAARSLQAMAVSVSVLQEER-----EGMRKLSAN-VDQLRTNVDRLQSLVNDEMK 483
            .:::|..|  .|..||:.......:..:|.     .|......| |.:|.:.|::|.|    |:|
  Rat    75 EVLKEVRTLQEAVDSLKKSCQDCKLQADEHPDPGGNGAETAEDNRVQELESQVNKLSS----ELK 135

  Fly   484 N---------------KLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEA 533
            |               :|.::|         |::..:....:.:.||: .:|.|:.....:|...
  Rat   136 NAKEEIQGLQGRLESLQLVNMN---------NIENYVDNKVANLTSVV-NSLDSKCFKCPSQEHN 190

  Fly   534 IINKLPH----DCSEVHT---QTDGLHLIAPAGQRHPLMTHC----TADGWTTVQRRFDGSADFN 587
            ..|.:.|    |||:.:.   ::.|.:.:.|..:......:|    |..|||.:|.|.|||.:|.
  Rat   191 QPNPVQHLIYKDCSDYYVLGKRSSGTYRVTPDHRNSSFEVYCDMETTGGGWTVLQARLDGSTNFT 255

  Fly   588 RSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRL 652
            |.|.||..|||....|||:||:::|.||......|::.::|.......|.|.:||:::....|||
  Rat   256 RGWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYAVYDQFYVANEFLKYRL 320

  Fly   653 HIAEYSGNASDALNYQQGMQ-----FSAIDDDRD-ISQTHCAANYEGGWWFSHCQHANLNGRY-- 709
            |:..|:|.|.|||.:.:...     |:..|.|.| ....:|...|..||||..|..|||||:|
  Rat   321 HLGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYH 385

  Fly   710 ------NLGLTWFDAARNEWIAV------------KSSRMLVK 734
                  ..|:.|     ..|..|            |.::|:::
  Rat   386 QRYKGVRNGIFW-----GTWPGVSQAHPGGYKFSFKKAKMMIR 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	71/234 (30%)
Fgl2	NP_445907.2	ApoLp-III_like	<71..177	CDD:304399	22/119 (18%)
Fgl2	NP_445907.2	Fibrinogen_C	199..425	CDD:278572	70/230 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810