DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and TNXB

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001352205.1	Gene:	TNXB / 7148	HGNCID:	11976	Length:	4244	Species:	Homo sapiens

Alignment Length:	898	Identity:	188/898 - (20%)
Similarity:	296/898 - (32%)	Gaps:	287/898 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNAL 137
            |...|.:.....|:|...||.|...|.:.|....:...:.:|||.......|:|     :::...
Human  3352 TKPSPRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQ-----REVTVQ 3411

  Fly   138 MLRRREDYEMLEHNLRKSLRL-TTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQ 201
            .|.....|..|.:.|....|| ..:|:|..|.:..||.....||.....:.|.    |.:.|
Human  3412 GLEPSRKYRFLLYGLSGRKRLGPISADSTTAPLEKELPPHLGELTVAEETSSS----LRLSW--- 3469

  Fly   202 TISE-------IRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQL--------------K 245
            |:::       ::.:..|.|..|..||.|  ||:.|.|||...:. |:.|              .
Human  3470 TVAQGPFDSFVVQYRDTDGQPRAVPVAAD--QRTVTVEDLEPGKK-YKFLLYGLLGGKRLGPVSA 3531

  Fly   246 LDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRK-------------DGSSASVE 297
            |.:.|..|     :....||..|..:..::.:..::.:...|..             |......|
Human  3532 LGMTAPEE-----DTPAPELAPEAPEPPEEPRLGVLTVTDTTPDSMRLSWSVAQGPFDSFVVQYE 3591

  Fly   298 EESGSQEA-----NQEQ---------------------------------TGL----ETTADHKR 320
            :.:|..:|     :|.:                                 |||    :|:.:.:.
Human  3592 DTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLSAEGTTGLAPAGQTSEESRP 3656

  Fly   321 RHCRFQSEQI---------------------------------HQLQLAQRNLR----------R 342
            |..:.....:                                 |...|.||.|.          |
Human  3657 RLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMVPGTRHSAVLR 3721

  Fly   343 QVN----------GLRFHH--------------IDERVRSIEVEQHRIANA------------NF 371
            .:.          |||..|              :.|..|.::..:.|..:|            :|
Human  3722 DLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSEIRETSAKVNWMPPPSRADSF 3786

  Fly   372 NLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLE---FANAQITSEQSLIREEG 433
            .:|.|:|...:..:..:    |.:....|:...||..|:|::.:.   |..::..:.......:|
Human  3787 KVSYQLADGGEPQSVQV----DGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVPDG 3847

  Fly   434 TNAARSL-----------------------QAMAVSVSVLQEEREGM------------RKLSAN 463
            ....|:|                       |..|.....||.|..|.            ...:|.
Human  3848 PTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAETPGSAVDYPLHDLVLHTNYTAT 3912

  Fly   464 VDQLR-------------TNVDRLQSLVNDEM--KNKLTHLNKPHKRP------HH----QNVQA 503
            |..||             |.::..:.|...|:  :..|....:|..||      .|    ||.:.
Human  3913 VRGLRGPNLTSPASITFTTGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEI 3977

  Fly   504 QMPQDDSPIDSVLAETLVSELENVETQYEAIINKL----------------------PHDCSEVH 546
            .:|      ..:.:..|:....:  |.|.|.:..:                      |.||.|..
Human  3978 LLP------GGITSHQLLGLFPS--TSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEM 4034

  Fly   547 TQTDGLH----LIAPAGQRHPLMTHCTAD----GWTTVQRRFDGSADFNRSWADYAQGFGAPGGE 603
            ....|..    :.....:..||...|..:    ||...|||.||..||.|.|.|||.|||...||
Human  4035 QNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGE 4099

  Fly   604 FWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQ 668
            ||:|||.||.||......::|.:: ..|....|:|..|::.|.|:.||||:..|.|.|.|:::|.
Human  4100 FWLGNEALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYH 4163

  Fly   669 QGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRY-----NLGLTWF 716
            .|..|||.|.|.:.....||.:|.|.||:.:|.:|||||.|     :.|::|:
Human  4164 SGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWY 4216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	24/133 (18%)
sca	NP_476710.2	FBG	538..736	CDD:214548	73/214 (34%)
TNXB	NP_001352205.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..189
		EGF_2	189..213	CDD:285248
		EGF_2	216..244	CDD:285248
		VSP	<254..669	CDD:333463
		EGF_2	621..647	CDD:285248
		fn3	762..831	CDD:306538
		fn3	843..919	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	926..956
		fn3	1061..1141	CDD:306538
		FN3	1156..1238	CDD:238020
		fn3	1265..1342	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1372
		fn3	1376..1446	CDD:306538
		fn3	1475..1555	CDD:306538
		fn3	1578..1643	CDD:306538
		Cell attachment site. /evidence=ECO:0000255	1666..1668
		fn3	1672..1739	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1752..1777
		FN3	1773..1862	CDD:238020
		fn3	1885..1955	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1990
		fn3	1988..2061	CDD:306538
		fn3	2099..2169	CDD:306538
		fn3	2198..2268	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2281..2304
		fn3	2304..2377	CDD:306538
		fn3	2418..2485	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2495..2542
		fn3	2526..2596	CDD:306538
		fn3	2629..2709	CDD:306538
		fn3	2743..2810	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2824..2847
		fn3	2845..2925	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2933..2969
		fn3	2959..3026	CDD:306538
		fn3	3061..3134	CDD:306538
		fn3	3170..3240	CDD:306538
		fn3	3263..3328	CDD:306538
		fn3	3354..3436	CDD:306538	19/86 (22%)
		fn3	3453..3515	CDD:306538	19/71 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3536..3559		5/27 (19%)
		fn3	3562..3637	CDD:306538	6/74 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3636..3662		5/25 (20%)
		fn3	3656..3738	CDD:306538	9/81 (11%)
		fn3	3758..3836	CDD:306538	14/81 (17%)
		FN3	3845..3931	CDD:238020	13/85 (15%)
		fn3	3935..4012	CDD:306538	14/84 (17%)
		Fibrinogen_C	4026..4235	CDD:278572	73/192 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810