DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and TNR

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens

Alignment Length:	697	Identity:	157/697 - (22%)
Similarity:	255/697 - (36%)	Gaps:	174/697 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 NLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQT--ISEIRKQLVDL 213
            |.::|:..|.||       |:||:..|:.:....|..|     :::.|.:.:  |...|......
Human   671 NSQQSVPATMNA-------RTELDSPRDLMVTASSETS-----ISLIWTKASGPIDHYRITFTPS 723

  Fly   214 QRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQH 278
            ...||.|.....:.|.|..||.. .::|   .:.:.|:|.|||..|..|.............|.|
Human   724 SGIASEVTVPKDRTSYTLTDLEP-GAEY---IISVTAERGRQQSLESTVDAFTGFRPISHLHFSH 784

  Fly   279 ALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQ-----------IHQ 332
            ........|..|.|..:..........::|:..:|.:.|..:||......|           :|.
Human   785 VTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVAVHG 849

  Fly   333 LQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLD------------KLHT 385
            ...::..:.....|:      :..:.|.:......:...:.|..:||.|            :|.:
Human   850 TVTSEPIVGSITTGI------DPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRPTQVGRLDS 908

  Fly   386 SML------------------EL-LEDVEG----------LQTKMDKSIPELRHEISKLE----- 416
            |::                  |: |..|.|          :.|.||..:..:...|:..|
Human   909 SVVPNTVTEFTITRLNPATEYEISLNSVRGREESERICTLVHTAMDNPVDLIATNITPTEALLQW 973

  Fly   417 ----------------FANAQITSEQSLIREE-----------------GTNAARSLQAMAVSVS 448
                            ||.|..|.....:.||                 .||...:...::.:.|
Human   974 KAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTATMYATNGPLTSGTISTNFS 1038

  Fly   449 VLQEEREGMRKLSANVDQLRTNVDRLQSLVN-----DEMKN-KLTHLNKPHKRPHHQNVQAQMPQ 507
            .|         |....:...:.|.|..:|::     .|::| .||:.:....|.     :..:..
Human  1039 TL---------LDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDGSRK-----ELIVDA 1089

  Fly   508 DDSPIDSVLAETLVSELENV----------ETQYEAIINKL----------PHDCSEVHTQTDGL 552
            :|:.|      .|...|||.          :|.:.:|.:..          |.||::.....|.|
Human  1090 EDTWI------RLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQHLMNGDTL 1148

  Fly   553 HLIAPA---GQ-RHPLMTHC--TAD--GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNE 609
            ..:.|.   |: ...|..:|  |.|  ||...|||.:|..||.|.||||..|||....|||:|.:
Human  1149 SGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNVEDEFWLGLD 1213

  Fly   610 QLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFS 674
            .:|.:|......|:|.|:|..:..: |.|.||.:....:.|:|.|..|:|.|.|:|:|.||..||
Human  1214 NIHRITSQGRYELRVDMRDGQEAAF-ASYDRFSVEDSRNLYKLRIGSYNGTAGDSLSYHQGRPFS 1277

  Fly   675 AIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRY-----NLGLTWF 716
            ..|.|.|::.|:||.:|:|.||:.:|...||||:|     :.|:.|:
Human  1278 TEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWY 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	22/101 (22%)
sca	NP_476710.2	FBG	538..736	CDD:214548	72/202 (36%)
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248
		EGF_2	267..292	CDD:285248
		EGF_2	299..323	CDD:285248
		fn3	328..398	CDD:278470
		fn3	416..496	CDD:278470
		fn3	505..583	CDD:278470
		FN3	595..679	CDD:238020	2/7 (29%)
		fn3	687..766	CDD:278470	19/87 (22%)
		fn3	776..855	CDD:278470	12/78 (15%)
		fn3	865..944	CDD:278470	11/78 (14%)
		fn3	954..1026	CDD:278470	10/71 (14%)
		FN3	1042..1127	CDD:238020	16/95 (17%)
		FReD	1133..1342	CDD:238040	72/193 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810