DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and fn1

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001025695.1	Gene:	fn1 / 595087	XenbaseID:	XB-GENE-484447	Length:	2475	Species:	Xenopus tropicalis

Alignment Length:	829	Identity:	160/829 - (19%)
Similarity:	269/829 - (32%)	Gaps:	262/829 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHSKQET-------------EAP 88
            :.:|.||.:|.:|....|.|      .|...:..|.|:...:.|.|..|             |.|
Frog  1683 VTIVGLQPAVEYVVSIYSQG------ENGESEPLVETAVTNIDHPKGLTFTDVGVDSIRLAWEVP 1741

  Fly    89 ESSV---------------ELLRFVDDDEDSEDISSIERQDGRT---------MESKKMA----- 124
            :..|               ||....:.|:|:.::..:......|         ||||.|.
Frog  1742 DGQVTRYRVTYSSPEEGVKELFPAPEGDDDTAELHGLRPGTEYTVSIVALHDDMESKPMIGIQST 1806

  Fly   125 ----------DQV---------RLLTKQLNALMLR---RREDYEMLEHNLRKSLRLTTNANSVDA 167
                      .||         ...|..|:..::|   :.:...|.|..|...:..||....:.|
Frog  1807 AIPAPTNLQFSQVTPSGFSLSWHAPTIHLSGYLVRVNPKEKTGPMKEVRLSPGVTATTVTGLMVA 1871

  Fly   168 DMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVA-------QDVQ 225
             .:.|:|     :.||       |:.||.:.||..||           |..||:       |||.
Frog  1872 -TKYEVN-----VYAL-------KDTLTSQPLQGLIS-----------TLDNVSPPRRPRVQDVT 1912

  Fly   226 QRSSTFE---DLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRT 287
            :.:.|..   ...|| :.:|...:....|...::..:..::......||...|::..|..|....
Frog  1913 ETTVTLSWRTKTETI-TGFQIDAIPAGGQNPIRRTVDADLRSFTITGLQPGTDYKIYLYTLNDNA 1976

  Fly   288 RKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNG--LRF- 349
            |.......|                 |||.....:.||.:...:.|....:..|.::.|  :|:
Frog  1977 RSSPVIVDV-----------------TTAVDSPSNLRFLTTTSNSLLFTWQPPRARITGYIIRYE 2024

  Fly   350 -------HHI--------DERVRSIEVEQ----HRIANANFNLSSQIA------SLDKLHT---- 385
                   .|:        :..:.::|...    :.||..|...|..:.      .|.:|.|
Frog  2025 KAGGLLKEHLPRLQAGTTESTITNLEPGTEYIVYIIAVRNNQKSEPLVGRKRTDELPRLVTLPHP 2089

  Fly   386 ----SMLELLEDVEG----LQTKMDKSIPELRHEISKLEFANAQITS---EQSLIREEGTNAARS 439
                .:|::..|.|.    .|.|:|..      ...:|..:|.|..|   |..||.|.|   .||
Frog  2090 GKGPEILDVPTDEENTPHITQIKLDNG------NGIQLPGSNGQQPSSGNEGQLIEEHG---FRS 2145

  Fly   440 LQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQ 504
            ..|...:|.|    |.| :....:..|.|.:::     ::.|...:...|:.|:  ||....|.
Frog  2146 PLAPTTAVPV----RPG-KFTPGHYPQERVDIE-----LDTEFPVQRGDLDGPY--PHGLGPQL- 2197

  Fly   505 MPQDDSPIDSVLAETLVS---ELENVETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQRHPLMT 566
               :||.:..|.:.|.:|   |||.  |:|....:.:.||.:.:..:..|            ..:
Frog  2198 ---NDSGVQEVASHTTISWRPELET--TEYIISCHPIEHDEAPLQFRVPG------------TSS 2245

  Fly   567 HCTADGWTTVQRRFDGSADFN-----RSWADYAQGF------GAPGGEFWIGNEQLHHLTLDNCS 620
            ..|.:|.|.       .|.:|     :..:|..:.|      |:||..     |.:.....|.|
Frog  2246 SATLNGLTQ-------GATYNIIVEAQKGSDKHKVFEKRVTVGSPGSP-----EGVLQPAEDTC- 2297

  Fly   621 RLQVQMQDIYDNVWVAEYK--RFYISSRADGYRLH---IAEYSGN---------ASDALNYQQGM 671
                     ||....|.|.  :.:......|:||.   :...||:         ..:.:|::.|.
Frog  2298 ---------YDTFNGAHYSVGQEWERMSESGFRLWCKCLGYGSGHFRCDSSKWCHDNGVNHRVGE 2353

  Fly   672 QFSAIDDDRDISQTHCAANYEGGWWFSHCQHANL----NGR-YNLGLTW 715
            ::....::..:....|..|.:|.:   .|:....    .|: ||:|..|
Frog  2354 KWDRRGENGQMMSCTCLGNGKGEF---KCEPHEATCYDEGKMYNVGEQW 2399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	21/109 (19%)
sca	NP_476710.2	FBG	538..736	CDD:214548	36/208 (17%)
fn1	NP_001025695.1	fn1	50..85	CDD:365828
		fn1	95..133	CDD:365828
		fn1	139..177	CDD:365828
		FN1	184..228	CDD:214494
		fn1	229..268	CDD:365828
		FN1	303..341	CDD:238018
		FN2	349..397	CDD:128373
		FN2	409..457	CDD:128373
		fn1	466..504	CDD:365828
		fn1	520..551	CDD:365828
		fn1	557..595	CDD:365828
		fn3	607..687	CDD:365830
		fn3	722..793	CDD:365830
		fn3	807..886	CDD:365830
		fn3	903..983	CDD:365830
		fn3	993..1070	CDD:365830
		fn3	1087..1154	CDD:365830
		fn3	1171..1253	CDD:365830
		fn3	1263..1344	CDD:365830
		fn3	1354..1433	CDD:365830
		fn3	1445..1525	CDD:365830
		fn3	1535..1614	CDD:365830
		fn3	1629..1709	CDD:365830	8/31 (26%)
		fn3	1721..1799	CDD:365830	13/77 (17%)
		fn3	1809..1889	CDD:365830	18/92 (20%)
		fn3	1901..1980	CDD:365830	14/79 (18%)
		fn3	1990..2070	CDD:365830	12/79 (15%)
		fn3	2210..2267	CDD:365830	14/77 (18%)
		FN1	2297..2341	CDD:214494	10/53 (19%)
		FN1	2342..2383	CDD:214494	6/43 (14%)
		FN1	2385..2424	CDD:238018	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100