DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and CG41520

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001104019.1	Gene:	CG41520 / 5740294	FlyBaseID:	FBgn0087011	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	171/843 - (20%)
Similarity:	312/843 - (37%)	Gaps:	229/843 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAF-----VSGAASGGVVLSDVNNML----- 66
            :||:||..|              ::.....:.||..:     |||.:.......:||:.|
  Fly     5 RKKISRMAL--------------VVTCYYFIHISYKYAYATSVSGTSRTVAGNGNVNHRLPRTSA 55

  Fly    67 ----RDAKVVTSEKPVVHSKQETEAPESSV---ELLRFVDDDEDSEDISSIERQDGRTMESKKMA 124
                ..|...|:.|.|..||..|......:   :||...:        ..|:..:|:......:.
  Fly    56 SYFGSGASANTNFKTVTKSKNVTRYGNIHIREQQLLNIFE--------VIIDTLEGKLKRIDSLD 112

  Fly   125 DQVRLLTKQLNALMLRRREDYEMLEHNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSG 189
            :.|.||.|.:..|..|       :.:|:.|:..:.:...:::..:.:|:.|          .||.
  Fly   113 NTVDLLMKNMETLQNR-------VVNNVLKTDFIISQLKNIEKTISNEMLQ----------GQSS 160

  Fly   190 NKERL--TVEWLQQTISEIRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKL-DLAAQ 251
            |....  |.:..|.:.:.:::|:|:|.|..|::...:        :...::.|...|.: |..|:
  Fly   161 NLNVAYETTKITQNSSTLLKEQIVNLDRKVSDIDNKL--------ECMKVQLDNNLLHVEDFNAE 217

  Fly   252 RERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTA 316
            ...::...:.|.::.:.:         :.|.:.|.|                   .|.:.|..:.
  Fly   218 ASEKKPVTINVNDVTKAL---------SYVAMTQVT-------------------SELSELRDST 254

  Fly   317 DHKRRHCRF----QSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQI 377
            |:..:..:|    .||.|.::    .::..:::....|| :.:.:.:.|..|..:|....|..:|
  Fly   255 DNIDKKLQFYINIASENIGKM----TSMMHEIHCAVVHH-NNQFKFLNVTTHSKSNNINKLVKEI 314

  Fly   378 ASLDKLHTSMLELLEDVEGLQTK-------------------MDKSIPELRHE--------ISKL 415
            ..:..: :...:.:.|| |:.||                   .:::|.|:.|:        |:..
  Fly   315 RPMGVV-SEQNDNVWDV-GVDTKSTDGHLLSKSTAPLSQTQRQERAIDEIHHDKKPKSYLNINNF 377

  Fly   416 EFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRK--LSANVDQLRTNV------- 471
            :....|...:::....|..:..|..:|:........:..|..|.  |..::..::..:
  Fly   378 DMVKKQFEKQENFKPPEEISETRIKEALEYESKNYTDTDENSRTEILLLSLSNIQPTIVNKTITT 442

  Fly   472 ---------DRLQSLVNDEMKNKLTHLNKP-------------------HKRPHHQNVQAQMPQD 508
                     |.|..|.::.:.:..||.|.|                   .|:|...|.
  Fly   443 PFTSTPGDGDVLGPLHSESLDSNRTHYNGPAVNGLKSANRKDRIIFPSIKKKPAFLNT------- 500

  Fly   509 DSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEV---HTQTDGLHLIAPAGQRH-PLMTHC- 568
                             .:...:.|:.:.....|.::   ..:..|:..:...|..: .|..:|
  Fly   501 -----------------TISNDFWALKDVKGFSCVDILNAGMKQSGVFYLQIRGTTYWFLKVYCD 548

  Fly   569 ---TADGWTTVQRR---FDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQ 627
               |..|||.:|||   .|...:|||.||||..|||.|..:||:|||.::.||.:....|:|:::
  Fly   549 QETTDGGWTVIQRRDDFKDSRENFNRDWADYKNGFGEPSKDFWLGNENIYMLTNNEEYSLRVELE 613

  Fly   628 DIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALN---Y-QQGMQFSAIDDDRDISQTHCA 688
            |...|...|:|..|.|.|.||.|:|.|..|.|||.|:||   | .....||..:.|.|.|..:||
  Fly   614 DFEGNKRYAQYSHFKIHSEADYYKLEIDGYEGNAGDSLNDPWYGSNNSPFSTYNKDNDRSSLNCA 678

  Fly   689 ANYEGGWWFSHCQHANLNGRY---------NLGLTWFDAARNEW----IAVKSSRMLVK-RLP 737
            :..:||||:..|.. .|||.|         ..|:.||     .|    ..:|.|:|::: |:|
  Fly   679 SMLKGGWWWKSCGR-GLNGLYLHDPQDITARQGIVWF-----RWRGWDYTLKKSKMMIRPRIP 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	14/100 (14%)
sca	NP_476710.2	FBG	538..736	CDD:214548	76/226 (34%)
CG41520	NP_001104019.1	FReD	516..733	CDD:238040	76/222 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14151
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910