DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and fgl2a

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001020710.1	Gene:	fgl2a / 565637	ZFINID:	ZDB-GENE-030131-9506	Length:	451	Species:	Danio rerio

Alignment Length:	492	Identity:	116/492 - (23%)
Similarity:	212/492 - (43%)	Gaps:	94/492 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 LVKLQQRTRKDGSSAS--VEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRR 342
            |:.:.|.....||..|  |:...|:...:|.:.       .....|..:.|..:|:.:....::.
Zfish    11 LIAIWQEVEASGSGPSGVVDRAPGASSCSQVRL-------RPAGKCEDEEECPYQITMPPLTIQL 68

  Fly   343 QVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLEL-LEDVEGLQTKMDKSIP 406
            .   .:|..:::.|:              .|.|...::::|.:|.||. |:.|: |..:.|...|
Zfish    69 P---KQFRLLEKTVK--------------ELQSLKETVNRLKSSCLECSLKQVD-LNLQKDSGDP 115

  Fly   407 ELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSV----SVLQEEREGMRKLSANVDQL 467
            ....|.|:.:       :...:|.....:....:|.|.|.:    |.|:..|..:..|...:::|
Zfish   116 PTEGEQSRGQ-------TSMRVIHNGNDSDNDIVQNMQVKMNRMSSSLKNARAQINSLQGRLEEL 173

  Fly   468 R-TNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQY 531
            . .|:..::::|:.:::|....:||                        ::.|..| ....:.|.
Zfish   174 NLLNLQNVENIVDRKVENITGMVNK------------------------ISSTCTS-CPGQQLQL 213

  Fly   532 EAIINKLPHDCSEVH---TQTDGLHLIAPAGQRHPLMTHCTAD----GWTTVQRRFDGSADFNRS 589
            :.:.|..|.|||::.   .:.:.::.:.|..:......:|..:    |||.:|.|.:||..|||:
Zfish   214 QHLTNIPPRDCSDISMLGQRINKVYQVTPDPRNGSFAVYCDMESFGGGWTVIQHRINGSVSFNRT 278

  Fly   590 WADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHI 654
            ||||.:|||....|||:||:::|.||......|:::::|.......|:|.:||:|:....|||.:
Zfish   279 WADYKKGFGNLNSEFWLGNDKIHLLTKAKDMILRIELEDSEGTRGYAKYDQFYVSNEFLHYRLSV 343

  Fly   655 AEYSGNASDALNYQQGMQ-----FSAIDDDRD-ISQTHCAANYEGGWWFSHCQHANLNGRY---- 709
            :.|||.|.:||.:.:...     |:..|.|.| ....:|.|.|..||||..|..|||||:|
Zfish   344 SGYSGTAGNALQFSKHFNHDQKFFTTPDKDNDRYPSGNCGAYYGSGWWFDACMSANLNGKYYKTK 408

  Fly   710 ----NLGLTW--FDAARNEWI------AVKSSRMLVK 734
                ..|:.|  :..|.:|:.      |.|:.:|:::
Zfish   409 YKGKRDGIFWGTWPNATSEYYPTSFRQAYKNVKMMIR 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	6/21 (29%)
sca	NP_476710.2	FBG	538..736	CDD:214548	72/226 (32%)
fgl2a	NP_001020710.1	FReD	219..447	CDD:238040	72/227 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810