DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sca and ANGPTL4

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_005272541.1	Gene:	ANGPTL4 / 51129	HGNCID:	16039	Length:	424	Species:	Homo sapiens

Alignment Length:	425	Identity:	119/425 - (28%)
Similarity:	184/425 - (43%)	Gaps:	96/425 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 SSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAAR 438
            |.:.||.|:::.....||:..:||:...:::    |.::|.||   .::::..|..  :||..:.
Human    32 SPRFASWDEMNVLAHGLLQLGQGLREHAERT----RSQLSALE---RRLSACGSAC--QGTEGST 87

  Fly   439 SLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQ- 502
            .|       .:..|.|.....|.:...||:....|:|.|.: ::..:..||.|.|.|..|...|
Human    88 DL-------PLAPESRVDPEVLHSLQTQLKAQNSRIQQLFH-KVAQQQRHLEKQHLRIQHLQSQF 144

  Fly   503 ------------------AQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSE---VH 546
                              .::|:...|:|..         .||..     :::||.||.|   |.
Human   145 GLLDHKHLDHEVAKPARRKRLPEMAQPVDPA---------HNVSR-----LHRLPRDCQELFQVG 195

  Fly   547 TQTDGLHLIAPAGQRHPLMTHC--TAD-GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGN 608
            .:..||..|.|.|. .|.:.:|  |:| |||.:|||.|||.||||.|..|..|||.|.||||:|.
Human   196 ERQSGLFEIQPQGS-PPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGL 259

  Fly   609 EQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRF--YISSRADGYRLHI-AEYSGNASDALNYQQG 670
            |::|.:|.|..|||.||::|...|   ||..:|  ::......|.|.: |..:|..........|
Human   260 EKVHSITGDRNSRLAVQLRDWDGN---AELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSG 321

  Fly   671 MQ--FSAIDDDRDISQ-THCAANYE------------------GGWWFSHCQHANLNGRY----- 709
            :.  ||..|.|.|:.: .:||.:..                  |||||..|.|:||||:|
Human   322 LSVPFSTWDQDHDLRRDKNCAKSLSAPSVAQRPDHVPSPLTPAGGWWFGTCSHSNLNGQYFRSIP 386

  Fly   710 ------NLGLTWFDAARNEWIAVKSSRMLVKRLPA 738
                  ..|:.| ...|..:..::::.||::.:.|
Human   387 QQRQKLKKGIFW-KTWRGRYYPLQATTMLIQPMAA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	82/238 (34%)
ANGPTL4	XP_005272541.1	FReD	183..418	CDD:238040	82/239 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910