DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sca and Angptl4

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_954546.1	Gene:	Angptl4 / 362850	RGDID:	735058	Length:	405	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	113/436 - (25%)
Similarity:	190/436 - (43%)	Gaps:	89/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 RFQSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSML 388
            ||.|..  ::.|....|.:..:|||.|          ||:.|         .|:.:|::...:..
  Rat    34 RFASWD--EMNLLAHGLLQLGHGLREH----------VERTR---------GQLGALERRMAACG 77

  Fly   389 ELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEE 453
            ...:..:|...| |: :||.:        |...:.|.|:.::.:.:...:..|.:|      |::
  Rat    78 NACQGPKGTDPK-DR-VPEGQ--------APETLQSLQTQLKAQNSKIQQLFQKVA------QQQ 126

  Fly   454 REGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAE 518
            |. :.|.:..:..|::.:|.|..          |||:....:........:|.|
  Rat   127 RY-LSKQNLRIQNLQSQIDLLTP----------THLDNGVDKTSRGKRLPKMAQ----------- 169

  Fly   519 TLVSELENVETQYEAIINKLPHDCSEVHTQTD---GLHLIAPAGQRHPLMTHC--TAD-GWTTVQ 577
             |:....|...     :::.|.||.|:..:.:   ||..|.|.|. .|.:.:|  |:| |||.:|
  Rat   170 -LIGLTPNATR-----LHRPPRDCQELFQEGERHSGLFQIQPLGS-PPFLVNCEMTSDGGWTVIQ 227

  Fly   578 RRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFY 642
            ||.:||.|||:||..|..|||.|.||||:|.|::|.:|.|..|:|.||:||...|..:.::. .:
  Rat   228 RRLNGSVDFNQSWEAYKDGFGDPQGEFWLGLEKMHSITGDRGSQLAVQLQDWDGNAKLLQFP-IH 291

  Fly   643 ISSRADGYRLHIAEYSGNASDALNYQQ---GMQFSAIDDDRDI-SQTHCAANYEGGWWFSHCQHA 703
            :......|.|.:.|.:.|...|.|...   .:.||..|.|.|: ...:||.:..|||||..|.|:
  Rat   292 LGGEDTAYSLQLTEPTANELGATNVSPNGLSLPFSTWDQDHDLRGDLNCAKSLSGGWWFGTCSHS 356

  Fly   704 NLNGRY-----------NLGLTWFDAARNEWIAVKSSRMLVKRLPA 738
            ||||:|           ..|:.| ...:..:..::::.:|::.:.|
  Rat   357 NLNGQYFHSIPRQRQQRKKGIFW-KTWKGRYYPLQATTLLIQPMEA 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	75/218 (34%)
Angptl4	NP_954546.1	FReD	182..399	CDD:238040	75/219 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4522
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.050