DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sca and TNC

DIOPT Version :9

Sequence 1:NP_476710.2 Gene:sca / 36411 FlyBaseID:FBgn0003326 Length:799 Species:Drosophila melanogaster
Sequence 2:XP_016870167.1 Gene:TNC / 3371 HGNCID:5318 Length:2384 Species:Homo sapiens


Alignment Length:733 Identity:163/733 - (22%)
Similarity:272/733 - (37%) Gaps:203/733 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 HNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKER-LTVEWLQQ--------TISE 205
            |:|.:|.:.|.:.::..|.:...:.....:::...::.:|:..| ||...:.:        |||:
Human  1658 HSLHESQQFTVSGDAKQAHITGLVENTGYDVSVAGTTLAGDPTRPLTAFVITEALPLLENLTISD 1722

  Fly   206 IRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRS-----DYQQLKLDLAAQRERQQQ-------T 258
            |......:...||..|.|      :|  |.|:..     |.|:..|. ..||:.:.:       .
Human  1723 INPYGFTVSWMASENAFD------SF--LVTVVDSGKLLDPQEFTLS-GTQRKLELRGLITGIGY 1778

  Fly   259 EVYV---------QELREEML-QQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLE 313
            ||.|         :.||.|:: :.|.:..:.||                     .:|..:...|.
Human  1779 EVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLV---------------------SDATPDGFRLS 1822

  Fly   314 TTADH--------KRRHCRFQSEQIHQLQLAQRNLRRQVNGLR---------------------- 348
            .|||.        |.|..:.|||.: ::.|......|.:.|||                      
Human  1823 WTADEGVFDNFVLKIRDTKKQSEPL-EITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVS 1886

  Fly   349 --------------FHHIDE-------RVRSIEVEQHRIANANFNLSS-QIASLD--KLHTSMLE 389
                          |..|.|       |..:.:||..||........: .:.::|  |..|.:::
Human  1887 AIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVK 1951

  Fly   390 LLEDVEGL-----QTKMDKSIPELRHEISKLE----FANAQITSEQSLIR--------------- 430
            |:..||.|     ....::|.|......:.|:    ...|.||..::|.|               
Human  1952 LIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISY 2016

  Fly   431 --EEGTNAARSLQAMAVSVSVLQEE-----------REGMRKLSANVDQLRTNVDRLQSLVNDEM 482
              |:.....|::....|..::...|           .:|.:|.|....:..|::|..:.|...|:
Human  2017 TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEV 2081

  Fly   483 KNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLV---------SELENVETQYEAIINKL 538
            :::...|.   .||...:|...:...:| :|..:.|.:|         ::| :..|.|.|.|..|
Human  2082 QSETALLT---WRPPRASVTGYLLVYES-VDGTVKEVIVGPDTTSYSLADL-SPSTHYTAKIQAL 2141

  Fly   539 ----------------------PHDCSEVHTQ---TDGLHLIAPAGQR-HPLMTHC--TAD--GW 573
                                  |.|||:....   |.||:.|...|.: ..|...|  |:|  ||
Human  2142 NGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGW 2206

  Fly   574 TTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEY 638
            ....||.:|..:|.::|..||.|||....|||:|.:.|:.:|......|:|.::| :.....|.|
Human  2207 IVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRD-HGETAFAVY 2270

  Fly   639 KRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHA 703
            .:|.:......|:|.:..|||.|.|::.|..|..||..|.|.|.:.|:||.:|:|.:|:.:|...
Human  2271 DKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRV 2335

  Fly   704 NLNGRY-----NLGLTWF 716
            ||.|||     :.|:.||
Human  2336 NLMGRYGDNNHSQGVNWF 2353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scaNP_476710.2 PRK13923 <200..300 CDD:276343 25/129 (19%)
FBG 538..736 CDD:214548 67/214 (31%)
TNCXP_016870167.1 EGF_2 377..403 CDD:285248
EGF_2 408..434 CDD:285248
EGF_2 468..496 CDD:285248
EGF_2 504..527 CDD:285248
EGF_2 533..558 CDD:285248
fn3 624..695 CDD:306538
fn3 713..793 CDD:306538
fn3 804..884 CDD:306538
fn3 894..976 CDD:306538
fn3 986..1064 CDD:306538
fn3 1075..1154 CDD:306538
fn3 1169..1241 CDD:306538
fn3 1260..1327 CDD:306538
fn3 1348..1427 CDD:306538
fn3 1439..1508 CDD:306538
fn3 1533..1605 CDD:306538
fn3 1619..1691 CDD:306538 5/32 (16%)
fn3 1716..1788 CDD:306538 19/80 (24%)
fn3 1804..1883 CDD:306538 17/100 (17%)
fn3 1894..1973 CDD:306538 16/78 (21%)
fn3 1985..2055 CDD:306538 9/69 (13%)
fn3 2071..2143 CDD:306538 17/76 (22%)
Fibrinogen_C 2163..2372 CDD:278572 66/192 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2579
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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