DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and Tnn

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_808507.2	Gene:	Tnn / 329278	MGIID:	2665790	Length:	1560	Species:	Mus musculus

Alignment Length:	860	Identity:	177/860 - (20%)
Similarity:	304/860 - (35%)	Gaps:	260/860 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VNNMLRDAKVVTSEKPVVHSKQETEAPESSVE--LLRFVDDDEDSEDI-------SSIER----- 112
            |.:.:.:..:..|..||          |:.::  ::|:...|.:::::       |::.|
Mouse   714 VTDQVTETTLSVSWDPV----------EADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPG 768

  Fly   113 -------------QDGRTMESKKMAD---QVRLLTKQLNALMLRRREDYEMLEHNL-RKSLRLTT 160
                         ||.|...:|...|   ...|:|:|:..  ......::.:|.:: |..:|.|
Mouse   769 VEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLVTEQVTE--STATVSWDPVEADIDRYVVRYT- 830

  Fly   161 NANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVAQDVQ 225
               |||.:.|..|....:....|...:.|.:.::.| |.|:...|.||       |::....|:.
Mouse   831 ---SVDGETREFLVGKDQTSTVLTGMRPGVEYQVDV-WAQKGTQESRK-------TSTKAPTDID 884

  Fly   226 QRSSTFEDLAT----------IRSDYQ----------------------------------QLKL 246
            ...:...|..|          :.:|..                                  :.|:
Mouse   885 GPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKV 949

  Fly   247 DLAAQRERQQQTE--------------VYVQELREEMLQ-----QEQDFQHALVKLQQRTRKDGS 292
            |:.||:..|...:              :.:.::.|..|.     .:.|....:|:.   |..||.
Mouse   950 DVWAQKGAQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRY---TSADGE 1011

  Fly   293 SASVEEESGSQEANQEQTGLETTADHK---------RRHCRFQSEQIHQLQLAQRNLRRQVNG-- 346
            |.  |...|.::.:...|||....::|         |...:..:|....:...:..:..||..
Mouse  1012 SK--EFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTEGHTDIDSPKNLVTNQVTENT 1074

  Fly   347 ----------------LRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVE 395
                            :|:...|...|.|.|.:                 :|..|.:..|...||
Mouse  1075 ATISWDPVQADIDRYMVRYTSADGETREIPVRK-----------------EKSSTVLTGLRPGVE 1122

  Fly   396 -GLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRK 459
             .:|....|...|.:...:|   |..:|.|.::|:....|....::....|..::   :|..:|.
Mouse  1123 YTVQVWAQKGARESKKAKTK---APTEIDSPKNLVTNRVTENTATISWDPVRANI---DRYMVRY 1181

  Fly   460 LSANVDQLRTNVDRLQSL---------------------VNDEMK---NKLTHLNKPHK-RP--- 496
            .||:.:.....|.:.||.                     ..:..|   ..||.::.|.. ||
Mouse  1182 TSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPPRNLRPFGV 1246

  Fly   497 -HHQNVQAQMPQDDSPIDSVL-----AETLVSELE------------------------------ 525
             |...|...:| ..:.||..:     ....|.|:|
Mouse  1247 THSGGVLTWLP-PSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQ 1310

  Fly   526 ---NVETQYEAIINKLPH--DCSEVHTQTD---GLHLIAPAGQ-RHPLMTHCTAD----GWTTVQ 577
               .|.|....:..:.||  |||:|...|:   ||:.|...|. ..|:..:|..|    ||...|
Mouse  1311 RSRTVSTTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQ 1375

  Fly   578 RRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQ--MQDIYDNVWVAEYKR 640
            ||..|..||.:.|..|.:|||.|..|||:|.::||:||....:|.:|:  :|...::.: |.|..
Mouse  1376 RRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFNESAY-AVYDF 1439

  Fly   641 FYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANL 705
            |.::|..:.|:|.:.:|.|.|.|||.|..|.:|:..|.|.||:.::||..:.||||:.:|..||.
Mouse  1440 FQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANP 1504

  Fly   706 NGRY-----NLGLTW 715
            ||:|     :.|:.|
Mouse  1505 NGKYGETKHSEGVNW 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	23/162 (14%)
sca	NP_476710.2	FBG	538..736	CDD:214548	72/195 (37%)
Tnn	NP_808507.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470	11/80 (14%)
		fn3	796..875	CDD:278470	20/92 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..888		5/26 (19%)
		fn3	884..961	CDD:278470	8/76 (11%)
		fn3	972..1049	CDD:278470	15/81 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1063		2/18 (11%)
		FN3	1060..1136	CDD:214495	14/92 (15%)
		fn3	1148..1225	CDD:278470	11/79 (14%)
		fn3	1236..1313	CDD:278470	11/77 (14%)
		FReD	1327..1539	CDD:238040	72/194 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910