DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and Angptl3

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_038941.1	Gene:	Angptl3 / 30924	MGIID:	1353627	Length:	455	Species:	Mus musculus

Alignment Length:	432	Identity:	116/432 - (26%)
Similarity:	200/432 - (46%)	Gaps:	84/432 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 EQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLE 392
            :..:.|.|....::.:...||     ....:::|:...:.|.:..|:|::.|          |||
Mouse    80 QSFYDLSLRTNEIKEEEKELR-----RTTSTLQVKNEEVKNMSVELNSKLES----------LLE 129

  Fly   393 DVEGLQTKMDKSIPELRHEISKLEFANA------QITSEQSLIREEGTNAARSLQAMAVSVSVLQ 451
            :...||.|    :..|..:::.|..:.|      ::||.:|.: |:..|:.|.|         ||
Mouse   130 EKTALQHK----VRALEEQLTNLILSPAGAQEHPEVTSLKSFV-EQQDNSIREL---------LQ 180

  Fly   452 EEREGMRKLSANVDQLRTNVDRLQSL-VNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSV 515
            ...|..::||....|::....:|:.. :.:..:|.|:.             :::.|:...|:.
Mouse   181 SVEEQYKQLSQQHMQIKEIEKQLRKTGIQEPSENSLSS-------------KSRAPRTTPPLQ-- 230

  Fly   516 LAETLVSELENVETQYEAIINKLPHDCSEVHTQ---TDGLHLIAPAGQRHPLMTHC-TADG--WT 574
                 ::|.||.|.      :.||.|||.|:.:   |.|::.|.|...: ....:| |..|  ||
Mouse   231 -----LNETENTEQ------DDLPADCSAVYNRGEHTSGVYTIKPRNSQ-GFNVYCDTQSGSPWT 283

  Fly   575 TVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYK 639
            .:|.|.|||.|||.:|.:|.:|||...||||:|.|:::.:...:...|::::||..|:....||.
Mouse   284 LIQHRKDGSQDFNETWENYEKGFGRLDGEFWLGLEKIYAIVQQSNYILRLELQDWKDSKHYVEYS 348

  Fly   640 RFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSH-CQHA 703
             |::.|....|.||:||.:||...||.....:.||.. :.|...|.:|..:|.||||::. |...
Mouse   349 -FHLGSHETNYTLHVAEIAGNIPGALPEHTDLMFSTW-NHRAKGQLYCPESYSGGWWWNDICGEN 411

  Fly   704 NLNGRYN-----------LGLTWFDAARNEWIAVKSSRMLVK 734
            ||||:||           .|:.|...:|..: |:|||:|:::
Mouse   412 NLNGKYNKPRTKSRPERRRGIYWRPQSRKLY-AIKSSKMMLQ 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	76/215 (35%)
Angptl3	NP_038941.1	Sufficient to inhibit LIPG/EL phospholipase activity. /evidence=ECO:0000250\|UniProtKB:Q9Y5C1	17..207		32/155 (21%)
		Sufficient to inhibit LPL lipase activity. /evidence=ECO:0000250\|UniProtKB:Q9Y5C1, ECO:0000269\|PubMed:20581395	17..165		20/103 (19%)
		Required for inhibition of LPL lipase activity. /evidence=ECO:0000250\|UniProtKB:Q9Y5C1	32..56
		SPEC	<34..191	CDD:295325	29/139 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..242		9/65 (14%)
		FReD	241..453	CDD:238040	76/216 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000