DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and Tnn

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001100659.2	Gene:	Tnn / 304913	RGDID:	1306002	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	190/849 - (22%)
Similarity:	324/849 - (38%)	Gaps:	209/849 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TFPDLQKKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAK 70
            |.||.:.|:|       |.:...|:.:...|...|..::.|....||              :|::
  Rat   742 TSPDGETKEV-------PVSKDKSSTVLRGLRPGVEYKVDVWAQKGA--------------QDSR 785

  Fly    71 VVTSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDI-------SSIERQDGRTMESKKMADQV- 127
            ...::.|......:....|...|....|..|....||       :|:   ||.|.|.....||.
  Rat   786 KANTKAPTDIDSPKNLVTEQVTESTATVSWDPVEADIDRYVVRYTSV---DGETREFLVGKDQTS 847

  Fly   128 RLLTKQLNALMLRRREDYEM---LEHNLRKSLRLTTNA-NSVDADMRSELNQLREELAALRSSQS 188
            .:||.      ::...:|::   .:...|:|.:.:|.| ..:|.......:|:.|
  Rat   848 TILTG------MKPGVEYQVDVWAQKGTRESRKTSTKAPTDIDGPKNLVTDQVTE---------- 896

  Fly   189 GNKERLTVEWLQQTISEIRKQLV-----DLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDL 248
               ..|:|.| ....::|.:.:|     |.:.....|::|   :|||.  |..:|... :.|:|:
  Rat   897 ---TTLSVSW-DPVEADIDRYMVRYTSPDGETKEVPVSKD---KSSTV--LRGLRPGV-EYKVDV 951

  Fly   249 AAQRERQQQTE--------------VYVQELREEMLQ-----QEQDFQHALVKLQQRTRKDGSSA 294
            .||:..|...:              :.:.::.|..|.     .:.|....:|:.   |..||.|.
  Rat   952 WAQKGAQDSRKANTKAPTDIDSPKNLAINQVTETTLSVSWDPVQADIDRYVVRY---TSADGESK 1013

  Fly   295 SVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNG---------LRFH 350
              |...|.::.:...|||....::|        .::...:.|:.:.:....|         |..:
  Rat  1014 --EFLIGKEQRSTVLTGLRPGVEYK--------VEVWAQKGARESKKANTKGHTDIDSPKNLVTN 1068

  Fly   351 HIDERVRSI-------EVEQH--RIANANFNLSSQIASLDKLHTSMLELLEDVE-GLQTKMDKSI 405
            .:.|...:|       :::::  |..:|:..........:|..|.:..|...|| .:|....|..
  Rat  1069 QVTENTATISWDPVQADIDRYMVRYTSADGETREVPVRKEKSSTVLTGLRPGVEYTVQVWAQKGA 1133

  Fly   406 PELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTN 470
            .|.|...:|   |..:|.|.::|:....|....::....|..::   :|..:|..||:.:.....
  Rat  1134 RESRKAKTK---APTEIDSPKNLVTNRVTENTATISWDPVRATI---DRYMVRYTSADGETKEVP 1192

  Fly   471 VDRLQSL---------------------VNDEMK---NKLTHLNKPHK-RP----HHQNVQAQMP 506
            |.:.||.                     ..:..|   ..||.::.|.. ||    |...|...||
  Rat  1193 VSKDQSSTILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPPKNFRPFGVTHSSGVLTWMP 1257

  Fly   507 ---QDDSPI------DSVLAETLVS------ELENVE----------------------TQYEAI 534
               |.|..|      :.:|.|..:.      ||:::|                      |....:
  Rat  1258 PSAQIDGYILTYQLPNGILKEVELQRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRSVSTTLSTV 1322

  Fly   535 INKLPH--DCSEVHTQTD----GLHLIAPAGQ-RHPLMTHCTAD----GWTTVQRRFDGSADFNR 588
            ..:.||  |||:|...|:    ||:.|...|. ..|:..:|..|    ||...|||..|..||.:
  Rat  1323 DARFPHPSDCSQVQQNTNAAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFK 1387

  Fly   589 SWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQ--MQDIYDNVWVAEYKRFYISSRADGYR 651
            .|..|.:|||.|..|||:|.::||:||....:|.:|:  :|...::.: |.|..|.::|..:.|:
  Rat  1388 RWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTANESAY-AVYDFFQVASSKERYK 1451

  Fly   652 LHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRY-----NL 711
            |.:.:|.|.|.|||.|..|.:|:..|.|.||:.::||..:.||||:.:|..||.||:|     :.
  Rat  1452 LSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGKYGETKHSE 1516

  Fly   712 GLTW 715
            |:.|
  Rat  1517 GVNW 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	24/123 (20%)
sca	NP_476710.2	FBG	538..736	CDD:214548	72/196 (37%)
Tnn	NP_001100659.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470	13/63 (21%)
		fn3	796..875	CDD:278470	18/87 (21%)
		fn3	884..961	CDD:278470	21/96 (22%)
		fn3	972..1049	CDD:278470	15/89 (17%)
		FN3	1060..1136	CDD:214495	12/75 (16%)
		FN3	1148..1224	CDD:214495	11/78 (14%)
		fn3	1236..1313	CDD:278470	15/76 (20%)
		FReD	1327..1540	CDD:238040	72/195 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910