DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and tncb

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001299845.1	Gene:	tncb / 30037	ZFINID:	ZDB-GENE-980526-104	Length:	1811	Species:	Danio rerio

Alignment Length:	914	Identity:	194/914 - (21%)
Similarity:	331/914 - (36%)	Gaps:	243/914 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WQTF-PDLQKKKVSRDHLNC-PATMAGSNVLWPILLAVVL-LQISVAFVSGAASGGVVLSDVNNM 65
            ::|| .||...|    ||.. ..|.....:.|....|.|| .::....:||...|.:|.......
Zfish   950 YETFTTDLDSPK----HLKAIEQTDESITLEWRNSRANVLNYRVKYGPLSGGEHGELVFPSGLQD 1010

  Fly    66 LRDAKVVTSEKP-------VVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKM 123
            ...|| :|..:|       |...|:|.|:..::...:..:|..:|.
Zfish  1011 TTQAK-ITGLRPGTEYGMGVTSIKEERESLPATTNAVTDLDPPKDL------------------- 1055

  Fly   124 ADQVRLLTKQLNALMLRRR----EDYEML---EHNLRKSLRLTTNANSV-----------DADMR 170
              ||...|:...||:.||.    :.|.::   ....:..|::...||:.           ...:.
Zfish  1056 --QVSETTETTLALVWRRPVAKIDTYSLVFIPADGDKTELKIPGAANTYILTGLNPGMLHTITLT 1118

  Fly   171 SELNQLREELAALRSS------QSGNKERLTVEWLQQTIS------EIRKQLVDLQ-----RTAS 218
            :|..:.....|.|.:|      |.||.....|.|...::|      |:...|:::.     ....
Zfish  1119 AERGRKMSAPATLSASTDEEKPQVGNITISDVSWDSFSMSWDLDRGEVEGFLIEVSDPDGLSDGQ 1183

  Fly   219 NVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQEL-----REEMLQQEQDFQH 278
            |.....|:.|....||:.  |.:.::.|           ..:|..||     .|.:.:.|.:.:|
Zfish  1184 NHTLSGQEFSLAVTDLSP--STFYRVTL-----------YGLYKGELLDPVFAEAITEAEPEVEH 1235

  Fly   279 ALVK-LQQRTRK----------DGSSASVEEESG----------SQEANQEQTGLETTADHKRRH 322
            ..|. :...:.|          |..:..|.:.||          ..:..:..|||....|
Zfish  1236 ITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTD----- 1295

  Fly   323 CRFQSEQIHQLQLAQRNLRRQV--------------NGLRFHHIDERVRSI-------EVEQHRI 366
                    ::::|....|.|:.              .|:||..:.:...::       .|:.:|:
Zfish  1296 --------YEIELFGIILGRKFQPIFTVARTGLGTPKGIRFSDVTDTSATVHWTMPHTRVDNYRV 1352

  Fly   367 ANANFNLSSQI----------ASLDKLH---TSMLELLEDVEGLQ----------TKMDKSIPEL 408
            ........|.:          |.|..|.   |..:.::. |:||:          |.:||.....
Zfish  1353 IYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIA-VKGLEESEPGSERVTTALDKPRGLT 1416

  Fly   409 RHEISKLEFANAQITSEQSLIREEGTNAARSLQAMA-----VSVSVLQEEREGM----------- 457
            ...||..|   |.:..:.|:...:|.....|..::|     ||.:.::.|...:
Zfish  1417 AVNISDTE---ALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVY 1478

  Fly   458 -----RKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLA 517
                 .|.:|......|:||..|:|....::.:...|.   .:|...::...:...:| .|.|:.
Zfish  1479 AFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLT---WKPPRADISGYILSFES-ADGVVK 1539

  Fly   518 ETLVSELE--------NVETQYE----------------------AIINKLPHDCSEV---HTQT 549
            |.::|...        ...|:|.                      .::.|.|.|||:.   ...|
Zfish  1540 EVVLSPTATFYSMSQLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTT 1604

  Fly   550 DGLHLIAPAG-QRHPLMTHC--TAD--GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNE 609
            .||:.|...| :..||..:|  |.|  ||....||..|..:|.|:|.:|..|||....|||:|..
Zfish  1605 SGLYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLS 1669

  Fly   610 QLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFS 674
            .||.:|......|:|.::|..::.: |:|.:|.||.....|::|:..|||.|.|::.|..|..||
Zfish  1670 NLHKITSFGQYELRVDLRDKGESAY-AQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFS 1733

  Fly   675 AIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRY-----NLGLTWFDAARNEWIAVKSSRMLVK 734
            ..|:|.||:.|:||.:|:|.:|:.:|...|:.|||     :.|:.||....:|. :|:.:.|.::
Zfish  1734 TYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEH-SVEFAEMKIR 1797

  Fly   735 RLPA 738
              ||
Zfish  1798 --PA 1799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	20/126 (16%)
sca	NP_476710.2	FBG	538..736	CDD:214548	73/210 (35%)
tncb	NP_001299845.1	DnaJ	<471..>544	CDD:333066
		fn3	689..760	CDD:306538
		fn3	778..858	CDD:306538
		fn3	868..948	CDD:306538
		FN3	958..1047	CDD:238020	20/93 (22%)
		fn3	1050..1128	CDD:306538	14/98 (14%)
		fn3	1140..1215	CDD:306538	16/87 (18%)
		fn3	1231..1303	CDD:306538	12/84 (14%)
		fn3	1323..1400	CDD:306538	13/77 (17%)
		fn3	1410..1482	CDD:306538	13/74 (18%)
		fn3	1498..1570	CDD:306538	12/75 (16%)
		FReD	1589..1798	CDD:238040	74/212 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810