Protein Alignment sca and ANGPTL3

DIOPT Version :9

• Sequence 1: NP_476710.2
• Gene: sca / 36411
• FlyBaseID: FBgn0003326
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_055310.1
• Gene: ANGPTL3 / 27329
• HGNCID: 491
• Length: 460
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 113/450 - (25%)
• Similarity: 199/450 - (44%)
• Gaps: 84/450 - (18%)

  Fly   356 VRSIEVEQHRIANANF-NLS----SQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKL 415
            |.|..::|.   |::| :||    |:.|.||.:......||:...||:..:.|:..::.....||
Human    14 VISSRIDQD---NSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKL 75

  Fly   416 EFANA---QITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMR-KLSANVDQLRTNVDRLQS 476
            ...:.   .::.:.|.|:||    .:.|:.....:.|..||.:.|. :|::.::.|......||.
Human    76 NIFDQSFYDLSLQTSEIKEE----EKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQ 136

  Fly   477 LVNDEMKNKLTHL--NKPHKRPHHQNV---QAQMPQDDSPIDSVL--AETLVSELENVETQYEAI 534
            .|. .::.:||:|  |:| :.|.|..|   :..:.:.|:.|..:|  .|....:|....:|.:.|
Human   137 KVK-YLEEQLTNLIQNQP-ETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEI 199

  Fly   535 INKL---------------------------------------PHDCSEVHTQ---TDGLHLIAP 557
            .|:|                                       |.:|:.::.:   |.|::.|.|
Human   200 ENQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRP 264

  Fly   558 AGQR--HPLMTHCTADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCS 620
            :..:  |......:...||.:|.|.|||.:||.:|.:|..|||...||||:|.|:::.:...:..
Human   265 SNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNY 329

  Fly   621 RLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQT 685
            .|:::::|..||....||. ||:.:....|.||:...:||..:|:...:.:.||.. |.:.....
Human   330 VLRIELEDWKDNKHYIEYS-FYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTW-DHKAKGHF 392

  Fly   686 HCAANYEGGWWF-SHCQHANLNGRYN-----------LGLTWFDAARNEWIAVKSSRMLV 733
            :|...|.||||: ..|...||||:||           .||:| .:......::||::||:
Human   393 NCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSW-KSQNGRLYSIKSTKMLI 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
		FBG	538..736	CDD:214548	65/251 (26%)
ANGPTL3	NP_055310.1	SMC_N	<84..>215	CDD:330553	31/136 (23%)
		FReD	243..453	CDD:238040	64/211 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910