DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sca and ANGPTL5

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_835228.2	Gene:	ANGPTL5 / 253935	HGNCID:	19705	Length:	388	Species:	Homo sapiens

Alignment Length:	425	Identity:	109/425 - (25%)
Similarity:	173/425 - (40%)	Gaps:	105/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 LSSQIASLDKLHTSMLELLEDVEG--LQTKMDKSIPELRHEISKLE---FANAQITSEQ------ 426
            :|...|||..|:..:....|.|:|  :....|.|:..:..:.|..:   .:|..:..|.
Human     2 MSPSQASLLFLNVCIFICGEAVQGNCVHHSTDSSVVNIVEDGSNAKDESKSNDTVCKEDCEESCD 66

  Fly   427 ---SLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSAN-VDQLRTNVDRLQSLVNDEMKNKLT 487
               .:.|||.....|:||...||.:      ...:||..| :|:.:.::|.|.:.||:.|...|
Human    67 VKTKITREEKHFMCRNLQNSIVSYT------RSTKKLLRNMMDEQQASLDYLSNQVNELMNRVL- 124

  Fly   488 HLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPH--------DCSE 544
                                           .|.:|:      :...::..||        ||::
Human   125 -------------------------------LLTTEV------FRKQLDPFPHRPVQSHGLDCTD 152

  Fly   545 VH------TQT-DGLHLIAPAGQRHPLMTHCTAD----GWTTVQRRFDGSADFNRSWADYAQGFG 598
            :.      |:| .||::|.|.|..:|....|..|    |.|.:|:|.||..||.|.|.||..|||
Human   153 IKDTIGSVTKTPSGLYIIHPEGSSYPFEVMCDMDYRGGGRTVIQKRIDGIIDFQRLWCDYLDGFG 217

  Fly   599 APGGEFWIGNEQLHHL-TLDNCS-RLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNA 661
            ...||||:|.:::.:: ...|.| .|.|.::...|.:..|.|..|::......:::|:..|||||
Human   218 DLLGEFWLGLKKIFYIVNQKNTSFMLYVALESEDDTLAYASYDNFWLEDETRFFKMHLGRYSGNA 282

  Fly   662 SDAL------NYQQGMQFSAIDDDRDISQTHCAANYEG-----------GWWFSHCQHANLNGRY 709
            .||.      :.|..|.||..|.|.|..:..|..|.:.           ||||:.|..|||||.:
Human   283 GDAFRGLKKEDNQNAMPFSTSDVDNDGCRPACLVNGQSVKSCSHLHNKTGWWFNECGLANLNGIH 347

  Fly   710 NL-------GLTWFDAARNEW-IAVKSSRMLVKRL 736
            :.       |:.|....:|.. :.:||..|.::|:
Human   348 HFSGKLLATGIQWGTWTKNNSPVKIKSVSMKIRRM 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	75/243 (31%)
ANGPTL5	NP_835228.2	FReD	146..382	CDD:238040	73/235 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810