DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sca and ANGPTL2

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_036230.1	Gene:	ANGPTL2 / 23452	HGNCID:	490	Length:	493	Species:	Homo sapiens

Alignment Length:	443	Identity:	121/443 - (27%)
Similarity:	189/443 - (42%)	Gaps:	79/443 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 VEQHRIANANFNLSSQIASL--DKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQIT 423
            |.|.|:..|....|.:...|  :::|...||||.: |.|:.|  :.|..|:    :|...:..|.
Human    60 VPQQRVTGAICVNSKEPEVLLENRVHKQELELLNN-ELLKQK--RQIETLQ----QLVEVDGGIV 117

  Fly   424 SEQSLIREEGTNA-ARSLQAMAVSVSVLQEEREGMRKLSANVDQ-LRTNVDRLQ--SLVNDEMKN 484
            ||..|:|:|..|. :|..|.....:..:..:|:...:||...:: |....|.||  |...| :::
Human   118 SEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKD-LEH 181

  Fly   485 KLTHL-------------------NKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQ 530
            |..||                   ..|..||..|...|..|:...|   .....:::::...|.|
Human   182 KYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQP---PTYNRIINQISTNEIQ 243

  Fly   531 YEAIINKLP-----------------------HDCSEV----HTQTDGLHLIAPAGQRHPLMTHC 568
            .:..:..||                       .||.:.    | .|..::|:.|......:...|
Human   244 SDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGH-DTSSIYLVKPENTNRLMQVWC 307

  Fly   569 ----TADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDI 629
                ...|||.:|||.|||.:|.|:|..|.||||...||:|:|.|.::.||.....:|.|.|:|.
Human   308 DQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDW 372

  Fly   630 YDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGG 694
            ......|||..|.:...::.|:|.:..|.|||.|:..:..|.||:.:|.|.|:...:||...:||
Human   373 SGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGG 437

  Fly   695 WWFSHCQHANLNG----------RYNLGLTWFDAARNEWIAVKSSRMLVKRLP 737
            ||::.|.|:||||          ||..|:.|.: .|....::|...|:::..|
Human   438 WWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAE-FRGGSYSLKKVVMMIRPNP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	73/238 (31%)
ANGPTL2	NP_036230.1	FReD	273..487	CDD:238040	71/215 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810