DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and FGG

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_068656.2	Gene:	FGG / 2266	HGNCID:	3694	Length:	453	Species:	Homo sapiens

Alignment Length:	427	Identity:	109/427 - (25%)
Similarity:	175/427 - (40%)	Gaps:	98/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 QTKMDKSIPELRHEISKLEFANAQITSEQSLIR--EEGTNAARSLQAMAVSVSVLQEER--EGMR 458
            |||:||.:..|...:.::|...:::   :.||:  :...|...|.:...:..:.|:..:  |.:.
Human    59 QTKVDKDLQSLEDILHQVENKTSEV---KQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIM 120

  Fly   459 KLSANVDQLRTNVDRLQSLVND------EMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLA 517
            |..|::....:::..||.:.|.      .:|.|:..|          ..|.|.|..|:
Human   121 KYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQL----------EAQCQEPCKDT------- 168

  Fly   518 ETLVSELENVETQYEAIINKLPHDCSEV---HTQTDGLHLIAPAGQRHPLMTHCTAD----GWTT 575
                       .|...|..|   ||.::   ..:..||:.|.|.......:.:|..|    |||.
Human   169 -----------VQIHDITGK---DCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTV 219

  Fly   576 VQRRFDGSADFNRSWADYAQGFG--APGG--EFWIGNEQLHHLTLDNC--SRLQVQMQDIYDNVW 634
            .|:|.|||.||.::|..|.:|||  :|.|  |||:|||::|.::..:.  ..|:|:::|......
Human   220 FQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTS 284

  Fly   635 VAEYKRFYISSRADGYRLHIAEYS-GNASDALN--------------YQQGMQFSAIDDDRDISQ 684
            .|:|..|.:...||.|||..|.:: |:|.||.:              ...|||||..|:|.|..:
Human   285 TADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFE 349

  Fly   685 THCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAA--------------RNEWIAVKSSRMLV-- 733
            .:||.....|||.:.|...:|||.|..|.|:..|:              :..|.::|.:.|.:
Human   350 GNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIP 414

  Fly   734 -KRLPAVECQANASASGAFVSVSGSAADAAPSSGATT 769
             .||...|.|.:.         .|.|....|...|.|
Human   415 FNRLTIGEGQQHH---------LGGAKQVRPEHPAET 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	72/242 (30%)
FGG	NP_068656.2	Fib_alpha	31..172	CDD:285864	26/143 (18%)
		FReD	175..414	CDD:294064	73/241 (30%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		5/21 (24%)
		Platelet aggregation and Staphylococcus clumping	423..437		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..453		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810