DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and FCN1

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001994.2	Gene:	FCN1 / 2219	HGNCID:	3623	Length:	326	Species:	Homo sapiens

Alignment Length:	216	Identity:	80/216 - (37%)
Similarity:	113/216 - (52%)	Gaps:	20/216 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 PHDCSEVHTQ---TDGLHLIAPAGQRHPLMTHCTAD----GWTTVQRRFDGSADFNRSWADYAQG 596
            |.:|.::..:   ..|.|.|.....| ||...|..|    |||..|||.|||.||.|.||.|.||
Human   115 PRNCKDLLDRGYFLSGWHTIYLPDCR-PLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQG 178

  Fly   597 FGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEY-SGN 660
            ||:..||||:||:.:|.||....|.|:|.:.|...|...|:||.|.::..|:.|:|.:..: .|:
Human   179 FGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGS 243

  Fly   661 ASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRYNL--------GLTWFD 717
            |.::|.......||..|.|.|:|.::||..::|.||::.|..:||||.|.:        |:.| .
Human   244 AGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINW-S 307

  Fly   718 AARNEWIAVKSSRMLVKRLPA 738
            ||:....:.|.|.|.|:  ||
Human   308 AAKGYKYSYKVSEMKVR--PA 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	78/212 (37%)
FCN1	NP_001994.2	Collagen	51..107	CDD:189968
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..111
		FReD	115..325	CDD:238040	78/213 (37%)
		A domain, contributes to trimerization	115..154		10/39 (26%)
		B domain, contributes to trimerization	155..243		39/87 (45%)
		Carbohydrate-binding. /evidence=ECO:0000269\|PubMed:17897951	282..284		0/1 (0%)
		P domain. /evidence=ECO:0000303\|PubMed:17148457	317..326		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810