DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and Angptl2

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_598253.2	Gene:	Angptl2 / 171100	RGDID:	620004	Length:	493	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	120/441 - (27%)
Similarity:	191/441 - (43%)	Gaps:	75/441 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 VEQHRIANA---NFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQI 422
            |.|.|:..|   | :...::...:::|...||||.: |.|:.|  :.|..|:    :|...:..|
  Rat    60 VPQQRVTGAICVN-SKEPEVHLENRVHKQELELLNN-ELLKQK--RQIETLQ----QLVEVDGGI 116

  Fly   423 TSEQSLIREEGTNA-ARSLQAMAVSVSVLQEEREGMRKLSANVDQ-LRTNVDRLQ--SLVNDEMK 483
            .||..|:|:|..|. :|..|.....:..:..:|:...:||...:: |....|.||  |...| ::
  Rat   117 VSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKD-LE 180

  Fly   484 NKLTHLNK-PHKR--------PHHQNVQAQMPQDDSP-------IDSVLAETLVSELENVETQYE 532
            :|..||.. .|.:        .|.|.|.|..|....|       ........:::::...|.|.:
  Rat   181 HKFQHLAMLAHNQSEVIAQLEEHCQRVPAARPVPQPPPATPPRVYQPPTYNRIINQISTNEIQSD 245

  Fly   533 AIINKLP-----------------------HDCSEV----HTQTDGLHLIAPAGQRHPLMTHC-- 568
            ..:..||                       .||.:.    |: |..::|:.|......:...|
  Rat   246 QNLKVLPPSLPTMPALTSLPSSTDKPSGPWRDCLQALEDGHS-TSSIYLVKPENTNRLMQVWCDQ 309

  Fly   569 --TADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYD 631
              ...|||.:|||.|||.:|.|:|..|.||||...||:|:|.|.::.||.....:|.|.|:|...
  Rat   310 RHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSG 374

  Fly   632 NVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWW 696
            ....|||..|.:...::.|:|.:..|.|||.|:..:..|.||:.:|.|.|:...:||...:||||
  Rat   375 RKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWW 439

  Fly   697 FSHCQHANLNG----------RYNLGLTWFDAARNEWIAVKSSRMLVKRLP 737
            ::.|.|:||||          ||..|:.|.: .|....::|...|:::..|
  Rat   440 YNACAHSNLNGVWYRGGHYRSRYQDGVYWAE-FRGGSYSLKKVVMMIRPNP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	73/238 (31%)
Angptl2	NP_598253.2	t_SNARE	156..>206	CDD:197699	12/50 (24%)
Angptl2	NP_598253.2	FReD	273..487	CDD:238040	71/215 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900