DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and Angpt4

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_033771.1	Gene:	Angpt4 / 11602	MGIID:	1336887	Length:	509	Species:	Mus musculus

Alignment Length:	531	Identity:	124/531 - (23%)
Similarity:	210/531 - (39%)	Gaps:	119/531 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRKDGSSASVEEES 300
            :::.|....:|.|...|.::.|....|.:| |::|:....:   |:||:|..:.:..|..|:.:.
Mouse    70 SLQRDLPASRLHLTDWRAQRAQRAQRVSQL-EKILENNTQW---LLKLEQSIKVNLRSHLVQAQQ 130

  Fly   301 GSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQV---------NGLRFHHIDERV 356
            .:.: ||..|.|...|:...:    ...|.|:|...:..:..|.         |.|..:.::.::
Mouse   131 DTIQ-NQTTTMLALGANLMNQ----TKAQTHKLTAVEAQVLNQTLHMKTQMLENSLSTNKLERQM 190

  Fly   357 RSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQ 421
            .....|..|:...|..|.:::.:|:..|.:.|              .|:.|.|.::..|
Mouse   191 LMQSRELQRLQGRNRALETRLQALEAQHQAQL--------------NSLQEKREQLHSL------ 235

  Fly   422 ITSEQSLIREEGT--NAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKN 484
                  |..:.||  |...:|.|::.:.|.||::::          ||...|.||..:|
Mouse   236 ------LGHQTGTLANLKHNLHALSSNSSSLQQQQQ----------QLTEFVQRLVRIV------ 278

  Fly   485 KLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVH--- 546
                                 .||..|:          .|:..:..::        ||:|:.
Mouse   279 ---------------------AQDQHPV----------SLKTPKPVFQ--------DCAEIKRSG 304

  Fly   547 TQTDGLHLIAPAGQRHPLMTHCTAD----GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIG 607
            ..|.|::.|.......||...|..:    |||.:|.|.|||.:|.|:|.:|.:|||....|.|:|
Mouse   305 VNTSGVYTIYETNMTKPLKVFCDMETDGGGWTLIQHREDGSVNFQRTWEEYKEGFGNVAREHWLG 369

  Fly   608 NEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNY-QQGM 671
            ||.:|.||......|:|::.|........:|:.|.:.|....|.|.:.:.|.:|....:. .||.
Mouse   370 NEAVHRLTSRTAYLLRVELHDWEGRQTSIQYENFQLGSERQRYSLSVNDSSSSAGRKNSLAPQGT 434

  Fly   672 QFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRYNL---------GLTWFDAARNEWIAVK 727
            :||..|.|.|.....||....|||||..|..:||||.|..         |:.| ...|....::.
Mouse   435 KFSTKDMDNDNCMCKCAQMLSGGWWFDACGLSNLNGIYYSVHQHLHKINGIRW-HYFRGPSYSLH 498

  Fly   728 SSRMLVKRLPA 738
            .:||:::.:.|
Mouse   499 GTRMMLRPMGA 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	15/63 (24%)
sca	NP_476710.2	FBG	538..736	CDD:214548	67/214 (31%)
Angpt4	NP_033771.1	BMFP	140..217	CDD:294701	13/80 (16%)
		FReD	292..507	CDD:238040	67/223 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..436		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000