DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sca and Angpt2

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_031452.2	Gene:	Angpt2 / 11601	MGIID:	1202890	Length:	496	Species:	Mus musculus

Alignment Length:	468	Identity:	126/468 - (26%)
Similarity:	210/468 - (44%)	Gaps:	105/468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 EQIHQLQLAQRNLRRQVNGLR--FHHIDERVRS--IEVEQHRIANANFNLSSQIASLDKLHTSML 388
            :.:.:||:.:..|......|.  .::|.:.::.  :|::|:.:.|       |.|.:.::.||:|
Mouse    75 DSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQN-------QTAVMIEIGTSLL 132

  Fly   389 -------ELLEDVEG-------------LQ-----TKMDKSIPELRHEISKLEFANAQITSEQSL 428
                   ..|.|||.             ||     .|::|.|.:...||:||:..|:.:  ||.:
Mouse   133 NQTAAQTRKLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQNKNSFL--EQKV 195

  Fly   429 IREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPH 493
            :..||.: :..||:|       :|::          |:|:..|.: ||.|.||::.||.....
Mouse   196 LDMEGKH-SEQLQSM-------KEQK----------DELQVLVSK-QSSVIDELEKKLVTATV-- 239

  Fly   494 KRPHHQNVQAQMPQDDSPIDSVLAET---LVSELENVETQYEAIINKLP----HDCSEVHTQ--- 548
                 .|...|..|.|      |.||   |::.:.:..::....|.|..    .||:|:...
Mouse   240 -----NNSLLQKQQHD------LMETVNSLLTMMSSPNSKSSVAIRKEEQTTFRDCAEIFKSGLT 293

  Fly   549 TDGLHLIAPAGQRHPLMTHCTAD----GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNE 609
            |.|::.:........:..:|..|    |||.:|.|.|||.||.|:|.:|.:|||:|.||:|:|||
Mouse   294 TSGIYTLTFPNSTEEIKAYCDMDVGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNE 358

  Fly   610 QLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQ-GMQF 673
            .:..||..:...|::|::|...|...:.|..||::.....||:|:...:|.|....:..| |..|
Mouse   359 FVSQLTGQHRYVLKIQLKDWEGNEAHSLYDHFYLAGEESNYRIHLTGLTGTAGKISSISQPGSDF 423

  Fly   674 SAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRY-----NL----GLTWFDAARNEW----IA 725
            |..|.|.|.....|:....|||||..|..:||||:|     |.    |:.|:     .|    .:
Mouse   424 STKDSDNDKCICKCSQMLSGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWY-----YWKGSGYS 483

  Fly   726 VKSSRMLVKRLPA 738
            :|::.|:::  ||
Mouse   484 LKATTMMIR--PA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	69/222 (31%)
Angpt2	NP_031452.2	RILP-like	<168..226	CDD:304877	21/78 (27%)
Angpt2	NP_031452.2	FBG	280..494	CDD:214548	69/220 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910