DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and angpt2b

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_571889.1	Gene:	angpt2b / 114408	ZFINID:	ZDB-GENE-010817-2	Length:	489	Species:	Danio rerio

Alignment Length:	526	Identity:	148/526 - (28%)
Similarity:	221/526 - (42%)	Gaps:	111/526 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 RQQQTE----VYVQELRE-EMLQQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLE 313
            ||.|.:    .|...|.| |..:...|||     :....::|..||   .||...|.:.::..||
Zfish    23 RQHQVQHGPCRYTFILPEVEQCRPAGDFQ-----VTNSLQRDSPSA---PESPHAEPSWQERKLE 79

  Fly   314 TTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRI-------ANANF 371
            |                  |:.|..|..:.:..|. .:|.|.||| |:|::.|       .....
Zfish    80 T------------------LESATENNTQWLQKLE-SYIQENVRS-EMERNVIHTQTATMLEIGT 124

  Fly   372 NLSSQIA----SLDKLHTSML--------ELLEDVEGLQT-KMDKSIPELRHEISKLEFANAQIT 423
            ||.||.|    .|..:.|.:|        :|||  ..|.| :::|.:.|...|:|:|...|:.:
Zfish   125 NLLSQSAENTCKLTDVETQVLNQTSRLEIQLLE--YSLSTNRLEKQLLEQTQEVSRLNDKNSYM- 186

  Fly   424 SEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDR---LQSLVNDEMKNK 485
             ||.....|..: :|.|||       :|:|::          ||...:||   |.||:..|:.:.
Zfish   187 -EQRFADMEAKH-SRELQA-------IQQEKQ----------QLLELLDRQNELVSLLEGELASS 232

  Fly   486 LTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVH---T 547
            ..:...         :|.|.......:..:||  :|:...::.|..:..:.|. .||:|:.   .
Zfish   233 TRNSTL---------IQRQQASLTDTVQQLLA--MVTHCNDISTPVDKEMLKF-RDCAEIFKSGV 285

  Fly   548 QTDGLHLIAPAGQRHPLMTHC----TADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGN 608
            ..:|::.|........:...|    ...|||..|.|:|||.||||.|.||..|||.|.||.|:||
Zfish   286 TENGIYSIHLPNSTQKIKVFCDMKTKGGGWTVFQHRYDGSVDFNRDWNDYKLGFGDPSGEHWLGN 350

  Fly   609 EQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNA--SDALNYQQGM 671
            :.:|.||......|||.::|..::...::|..|||......|.||...:||.|  :.:|.: .|.
Zfish   351 DVIHLLTTTKDYTLQVHLKDAEEHQAYSQYDTFYIDGEDKKYSLHARGFSGTAGRTSSLTH-SGT 414

  Fly   672 QFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNG----------RYNLGLTWFDAARNEWIAV 726
            |||..|.|.|.....||....|||||..|..:||||          ||| .:.|:......|:|.
Zfish   415 QFSTKDQDNDQCSCKCAQMATGGWWFEACGPSNLNGIYYSGNSNVIRYN-SIKWYYWKGPSWMAT 478

  Fly   727 KSSRML 732
            .::.|:
Zfish   479 MTTMMI 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	13/50 (26%)
sca	NP_476710.2	FBG	538..736	CDD:214548	74/214 (35%)
angpt2b	NP_571889.1	NYD-SP28	164..244	CDD:291438	25/108 (23%)
angpt2b	NP_571889.1	FReD	274..487	CDD:238040	74/214 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910